Vascular Aging Detected by Peripheral Endothelial Dysfunction Is Associated With ECG-Derived Physiological Aging.
Aging
/ physiology
Arteries
/ physiopathology
Artificial Intelligence
Cross-Sectional Studies
Electrocardiography
Endothelium, Vascular
/ physiopathology
Female
Follow-Up Studies
Humans
Male
Microvessels
/ physiopathology
Middle Aged
Peripheral Arterial Disease
/ physiopathology
Retrospective Studies
Risk Factors
Vasodilation
/ physiology
artificial intelligence
peripheral microvascular endothelial dysfunction
physiological age
reactive hyperemia peripheral arterial tonometry index
vascular age
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
02 02 2021
02 02 2021
Historique:
pubmed:
19
1
2021
medline:
14
10
2021
entrez:
18
1
2021
Statut:
ppublish
Résumé
Background An artificial intelligence algorithm that detects age using the 12-lead ECG has been suggested to signal "physiologic age." This study aimed to investigate the association of peripheral microvascular endothelial function (PMEF) as an index of vascular aging, with accelerated physiologic aging gauged by ECG-derived artificial intelligence-estimated age. Methods and Results This study included 531 patients who underwent ECG and a noninvasive PMEF assessment using reactive hyperemia peripheral arterial tonometry. Abnormal PMEF was defined as reactive hyperemia peripheral arterial tonometry index ≤2.0. Accelerated or delayed physiologic aging was calculated by the Δ age (ECG-derived artificial intelligence-estimated age minus chronological age), and the association between Δ age and PMEF as well as its impact on composite major adverse cardiovascular events were investigated. Δ age was higher in patients with abnormal PMEF than in patients with normal PMEF (2.3±7.8 versus 0.5±7.7 years;
Identifiants
pubmed: 33455414
doi: 10.1161/JAHA.120.018656
pmc: PMC7955452
doi:
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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