Extending hypofractionated stereotactic body radiotherapy to tumours larger than 70cc - effects and side effects.


Journal

Acta oncologica (Stockholm, Sweden)
ISSN: 1651-226X
Titre abrégé: Acta Oncol
Pays: England
ID NLM: 8709065

Informations de publication

Date de publication:
Mar 2021
Historique:
pubmed: 16 1 2021
medline: 19 8 2021
entrez: 15 1 2021
Statut: ppublish

Résumé

Stereotactic body radiotherapy (SBRT) for tumours ≥5 cm is poorly studied and its utility and feasibility is uncertain. We here report the Karolinska experience of SBRT in this setting. All patients had a gross tumour volume (GTV) ≥70 cc, a prescribed physical dose of at least 40 Gy and received treatment between 1995-2012. We included 164 patients with 175 tumours located in the thorax ( SBRT of tumours >5 cm in diameter may be an option for peripherally located lung and abdominal tumours. Histological origin and tumour location should be considered before treatment.

Sections du résumé

BACKGROUND AND PURPOSE OBJECTIVE
Stereotactic body radiotherapy (SBRT) for tumours ≥5 cm is poorly studied and its utility and feasibility is uncertain. We here report the Karolinska experience of SBRT in this setting.
MATERIAL AND METHODS METHODS
All patients had a gross tumour volume (GTV) ≥70 cc, a prescribed physical dose of at least 40 Gy and received treatment between 1995-2012.
RESULTS RESULTS
We included 164 patients with 175 tumours located in the thorax (
CONCLUSION CONCLUSIONS
SBRT of tumours >5 cm in diameter may be an option for peripherally located lung and abdominal tumours. Histological origin and tumour location should be considered before treatment.

Identifiants

pubmed: 33448899
doi: 10.1080/0284186X.2020.1866776
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

305-311

Auteurs

Vitali Grozman (V)

Section of Thoracic Radiology, Department of Imaging and Physiology, Karolinska University Hospital, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Eva Onjukka (E)

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Section of Radiotherapy Physics and Engineering, Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.

Peter Wersäll (P)

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Section of Radiotherapy, Department of Cancer, Karolinska University Hospital, Stockholm, Sweden.

Ingmar Lax (I)

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Section of Radiotherapy Physics and Engineering, Department of Medical Radiation Physics and Nuclear Medicine, Karolinska University Hospital, Stockholm, Sweden.

Georgios Tsakonas (G)

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Section of Head, Neck, Lung and Skin tumours, Department of Cancer, Karolinska University Hospital, Stockholm, Sweden.

Sven Nyren (S)

Section of Thoracic Radiology, Department of Imaging and Physiology, Karolinska University Hospital, Stockholm, Sweden.
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.

Rolf Lewensohn (R)

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Section of Head, Neck, Lung and Skin tumours, Department of Cancer, Karolinska University Hospital, Stockholm, Sweden.

Karin Lindberg (K)

Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden.
Section of Head, Neck, Lung and Skin tumours, Department of Cancer, Karolinska University Hospital, Stockholm, Sweden.

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Classifications MeSH