Mitochondrial DNA Dynamics in Reprogramming to Pluripotency.

Animals Cellular Reprogramming / genetics DNA, Mitochondrial / genetics Induced Pluripotent Stem Cells Mitochondria / genetics Mitochondrial Dynamics
heteroplasmy induced pluripotent stem cell mitochondrial DNA pluripotency reprogramming

Journal

Trends in cell biology
ISSN: 1879-3088
Titre abrégé: Trends Cell Biol
Pays: England
ID NLM: 9200566

Informations de publication

Date de publication:
04 2021
Historique:
received: 15 09 2020
revised: 09 12 2020
accepted: 11 12 2020
pubmed: 11 1 2021
medline: 15 12 2021
entrez: 10 1 2021
Statut: ppublish

Résumé

Mammalian cells, with the exception of erythrocytes, harbor mitochondria, which are organelles that provide energy, intermediate metabolites, and additional activities to sustain cell viability, replication, and function. Mitochondria contain multiple copies of a circular genome called mitochondrial DNA (mtDNA), whose individual sequences are rarely identical (homoplasmy) because of inherited or sporadic mutations that result in multiple mtDNA genotypes (heteroplasmy). Here, we examine potential mechanisms for maintenance or shifts in heteroplasmy that occur in induced pluripotent stem cells (iPSCs) generated by cellular reprogramming, and further discuss manipulations that can alter heteroplasmy to impact stem and differentiated cell performance. This additional insight will assist in developing more robust iPSC-based models of disease and differentiated cell therapies.

Identifiants

DOI: 10.1016/j.tcb.2020.12.009 PMID: 33422359 PMC: PMC7954944
pubmed: 33422359
pii: S0962-8924(20)30255-5
doi: 10.1016/j.tcb.2020.12.009
pmc: PMC7954944
mid: NIHMS1658177
pii:
doi:

Substances chimiques

DNA, Mitochondrial 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

311-323

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM127985
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA185189
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM073981
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016042
Pays : United States
Organisme : NCI NIH HHS
ID : R21 CA227480
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM114188
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009120
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007185
Pays : United States

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Alexander J Sercel (AJ)

Molecular Biology Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA 90095.

Natasha M Carlson (NM)

Department of Biology, California State University Northridge, CA, USA 91330; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA 90095.

Alexander N Patananan (AN)

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA 90095.

Michael A Teitell (MA)

Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA 90095; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA, USA 90095; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA, USA 90095; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA 90095; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research University of California, Los Angeles, Los Angeles, CA, USA 90095; Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA 90095; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA 90095. Electronic address: mteitell@mednet.ucla.edu.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Mitochondrial DNA Dynamics in Reprogramming to...
Recherchemedicale.com › Phénomènes génétiques › Reprogrammation cellulaire › Mitochondrial DNA Dynamics in Reprogramming to...
Recherchemedicale.com › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN mitochondrial › Mitochondrial DNA Dynamics in Reprogramming to...
Recherchemedicale.com › Cellules › Cellules souches › Cellules souches pluripotentes › Cellules souches pluripotentes induites › Mitochondrial DNA Dynamics in Reprogramming to...
Recherchemedicale.com › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Mitochondrial DNA Dynamics in Reprogramming to...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dynamique mitochondriale › Mitochondrial DNA Dynamics in Reprogramming to...