Phthalate mixtures in pregnancy, autistic traits, and adverse childhood behavioral outcomes.

Autistic Disorder Child Child, Preschool Environmental Exposure Environmental Pollutants / toxicity Female Humans Infant Male Phthalic Acids / toxicity Pregnancy Prenatal Exposure Delayed Effects
Autism Child behavior Externalizing behavior Mixture effects Phthalates Prenatal exposure

Journal

Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270

Informations de publication

Date de publication:
02 2021
Historique:
received: 11 08 2020
revised: 28 10 2020
accepted: 07 12 2020
pubmed: 9 1 2021
medline: 24 4 2021
entrez: 8 1 2021
Statut: ppublish

Résumé

Prenatal exposure to multiple phthalates is ubiquitous, and yet few studies have evaluated these exposures as a mixture in relation to child autistic traits and behavioral problems. To assess cumulative associations between prenatal phthalate mixtures and child behaviors, including effect modification by exposure timing and child sex. Analyses included 501 mother/child pairs from the multicenter pregnancy cohort The Infant Development and Environment Study (TIDES). Nine maternal urinary phthalate metabolites were measured in early and late pregnancy, and behavior was assessed at ages 4-5 years using composite T scores for the Behavioral Assessment System for Children (BASC-2), which measures several dimensions of child behavior, and the Social Responsiveness Scale (SRS-2), which measures social impairment consistent with autistic traits. We utilized weighted quantile sum (WQS) regressions to examine pregnancy period-specific associations between phthalate mixtures and behavioral outcomes. Full-sample 95% WQS confidence intervals are known to be anti-conservative, so we calculated a confirmatory p-value using a permutation test. Effect modification by sex was examined with stratified analyses. A one-quintile increase in the early pregnancy phthalate mixture was associated with increased SRS-2 total score (coefficient = 1.0, confirmatory p = 0.01) and worse adaptive skills (coefficient = -1.0, confirmatory p = 0.06) in both sexes. In sex-stratified analyses, the early pregnancy phthalate mixture was associated with increased SRS-2 total score in boys (coefficient = 1.2, confirmatory p = 0.04) and girls (coefficient = 1.0, confirmatory p = 0.10) and worse BASC-2 adaptive skills score in girls (coefficient = -1.5, confirmatory p = 0.06), while the late pregnancy phthalate mixture was associated with increased BASC-2 externalizing score in boys (coefficient = 1.3, confirmatory p = 0.03). Our results suggest cumulative adverse associations between prenatal phthalate mixtures and multiple facets of childhood behavior.

Sections du résumé

BACKGROUND
Prenatal exposure to multiple phthalates is ubiquitous, and yet few studies have evaluated these exposures as a mixture in relation to child autistic traits and behavioral problems.
OBJECTIVES
To assess cumulative associations between prenatal phthalate mixtures and child behaviors, including effect modification by exposure timing and child sex.
METHODS
Analyses included 501 mother/child pairs from the multicenter pregnancy cohort The Infant Development and Environment Study (TIDES). Nine maternal urinary phthalate metabolites were measured in early and late pregnancy, and behavior was assessed at ages 4-5 years using composite T scores for the Behavioral Assessment System for Children (BASC-2), which measures several dimensions of child behavior, and the Social Responsiveness Scale (SRS-2), which measures social impairment consistent with autistic traits. We utilized weighted quantile sum (WQS) regressions to examine pregnancy period-specific associations between phthalate mixtures and behavioral outcomes. Full-sample 95% WQS confidence intervals are known to be anti-conservative, so we calculated a confirmatory p-value using a permutation test. Effect modification by sex was examined with stratified analyses.
RESULTS
A one-quintile increase in the early pregnancy phthalate mixture was associated with increased SRS-2 total score (coefficient = 1.0, confirmatory p = 0.01) and worse adaptive skills (coefficient = -1.0, confirmatory p = 0.06) in both sexes. In sex-stratified analyses, the early pregnancy phthalate mixture was associated with increased SRS-2 total score in boys (coefficient = 1.2, confirmatory p = 0.04) and girls (coefficient = 1.0, confirmatory p = 0.10) and worse BASC-2 adaptive skills score in girls (coefficient = -1.5, confirmatory p = 0.06), while the late pregnancy phthalate mixture was associated with increased BASC-2 externalizing score in boys (coefficient = 1.3, confirmatory p = 0.03).
CONCLUSION
Our results suggest cumulative adverse associations between prenatal phthalate mixtures and multiple facets of childhood behavior.

Identifiants

DOI: 10.1016/j.envint.2020.106330 PMID: 33418196 PMC: PMC9291724
pubmed: 33418196
pii: S0160-4120(20)32285-6
doi: 10.1016/j.envint.2020.106330
pmc: PMC9291724
mid: NIHMS1822467
pii:
doi:

Substances chimiques

Environmental Pollutants 0
Phthalic Acids 0
phthalic acid 6O7F7IX66E

Types de publication

Journal Article Multicenter Study Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

106330

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES025169
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023271
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023271
Pays : United States

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Drew B Day (DB)

Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, WA 98101, USA. Electronic address: drew.day@seattlechildrens.org.

Brent R Collett (BR)

Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, WA 98101, USA; Department of Psychiatry and Behavioral Sciences, University of Washington, 1959 NE Pacific Street, Seattle, WA 98195, USA. Electronic address: brent.collett@seattlechildrens.org.

Emily S Barrett (ES)

Department of Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers School of Public Health, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA. Electronic address: emily.barrett@eohsi.rutgers.edu.

Nicole R Bush (NR)

Center for Health and Community, Department of Psychiatry and Behavioral Sciences, Weill Institute for Neurosciences, Department of Pediatrics, University of California, San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143, USA. Electronic address: nicole.bush@ucsf.edu.

Shanna H Swan (SH)

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 E. 102nd Street, CAM Building, 3 West, One Gustave L. Levy Place, New York, NY 10029, USA. Electronic address: shannahswan@gmail.com.

Ruby H N Nguyen (RHN)

Department of Epidemiology and Community Health, University of Minnesota, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA. Electronic address: nguyen@umn.edu.

Adam A Szpiro (AA)

Department of Biostatistics, University of Washington, 1705 Northeast Pacific Street, Seattle, WA 98195, USA. Electronic address: aszpiro@uw.edu.

Sheela Sathyanarayana (S)

Center for Child Health, Behavior, and Development, Seattle Children's Research Institute, 1920 Terry Ave, Seattle, WA 98101, USA; Department of Pediatrics, University of Washington, 1959 Northeast Pacific Street, Seattle, WA 98195, USA. Electronic address: sheela.sathyanarayana@seattlechildrens.org.

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Classifications MeSH

Recherchemedicale.com › Troubles mentaux › Troubles du développement neurologique › Troubles généralisés du développement de l'enfant › Trouble du spectre autistique › Trouble autistique › Phthalate mixtures in pregnancy, autistic...
Recherchemedicale.com › Personnes › Tranches d'âge › Enfant › Phthalate mixtures in pregnancy, autistic...
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Recherchemedicale.com › Personnes › Tranches d'âge › Nourrisson › Phthalate mixtures in pregnancy, autistic...
Recherchemedicale.com › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Acides phtaliques › Phthalate mixtures in pregnancy, autistic...
Recherchemedicale.com › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Phthalate mixtures in pregnancy, autistic...
Recherchemedicale.com › Maladies urogénitales › Maladies de l'appareil urogénital féminin et complications de la grossesse › Complications de la grossesse › Lésions prénatales › Effets différés de l'exposition prénatale à des facteurs de risque › Phthalate mixtures in pregnancy, autistic...