Ketamine in acute phase of severe traumatic brain injury "an old drug for new uses?"

Anesthetics, Dissociative / pharmacology Brain Injuries, Traumatic / drug therapy Humans Hypnotics and Sedatives / pharmacology Intracranial Pressure / drug effects Ketamine / pharmacology Time Factors
Agitation Cooperative sedation Ketamine Neuroprotection Secondary insult Sedation Traumatic brain injury

Journal

Critical care (London, England)
ISSN: 1466-609X
Titre abrégé: Crit Care
Pays: England
ID NLM: 9801902

Informations de publication

Date de publication:
06 01 2021
Historique:
received: 02 11 2020
accepted: 22 12 2020
entrez: 7 1 2021
pubmed: 8 1 2021
medline: 6 8 2021
Statut: epublish

Résumé

Maintaining an adequate level of sedation and analgesia plays a key role in the management of traumatic brain injury (TBI). To date, it is unclear which drug or combination of drugs is most effective in achieving these goals. Ketamine is an agent with attractive pharmacological and pharmacokinetics characteristics. Current evidence shows that ketamine does not increase and may instead decrease intracranial pressure, and its safety profile makes it a reliable tool in the prehospital environment. In this point of view, we discuss different aspects of the use of ketamine in the acute phase of TBI, with its potential benefits and pitfalls.

Identifiants

DOI: 10.1186/s13054-020-03452-x PMID: 33407737 PMC: PMC7788834
pubmed: 33407737
doi: 10.1186/s13054-020-03452-x
pii: 10.1186/s13054-020-03452-x
pmc: PMC7788834
doi:

Substances chimiques

Anesthetics, Dissociative 0
Hypnotics and Sedatives 0
Ketamine 690G0D6V8H

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

19

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Auteurs

Daniel Agustin Godoy (DA)

Neurointensive Care Unit, Sanatorio Pasteur, Catamarca, Argentina.
Intensive Care Unit, Hospital Carlos Malbran, Catamarca, Argentina.

Rafael Badenes (R)

Anesthesiology and Surgical-Trauma Intensive Care, University Clinic Hospital, Valencia, Spain.
Department of Surgery, University of Valencia, Valencia, Spain.
INCLIVA Research Medical Institute, Valencia, Valencia, Spain.

Paolo Pelosi (P)

Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy.
Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy.

Chiara Robba (C)

Anesthesia and Intensive Care, San Martino Policlinico Hospital, IRCCS for Oncology and Neurosciences, Genoa, Italy. kiarobba@gmail.com.
Department of Surgical Sciences and Integrated Diagnostics, University of Genoa, Genoa, Italy. kiarobba@gmail.com.

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Classifications MeSH

Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Anesthésiques › Anesthésiques généraux › Anesthésiques intraveineux › Anesthésiques dissociatifs › Ketamine in acute phase of severe traumatic...
Recherchemedicale.com › Plaies et blessures › Traumatismes du système nerveux › Traumatismes cranioencéphaliques › Lésions encéphaliques › Lésions traumatiques de l'encéphale › Ketamine in acute phase of severe traumatic...
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Recherchemedicale.com › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Hypnotiques et sédatifs › Ketamine in acute phase of severe traumatic...
Recherchemedicale.com › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Pression du liquide cérébrospinal › Pression intracrânienne › Ketamine in acute phase of severe traumatic...
Recherchemedicale.com › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures alicycliques › Cyclohexanes › Kétamine › Ketamine in acute phase of severe traumatic...
Recherchemedicale.com › Phénomènes physiques › Temps › Facteurs temps › Ketamine in acute phase of severe traumatic...