Nox4 mediates skeletal muscle metabolic responses to exercise.
3-Hydroxyacyl CoA Dehydrogenases
/ metabolism
Animals
Fatty Acids
/ metabolism
Hexokinase
/ genetics
Hydrogen Peroxide
/ metabolism
Lipid Metabolism
Male
Mice
Muscle, Skeletal
/ metabolism
NADPH Oxidase 4
/ deficiency
Oxidation-Reduction
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ metabolism
Physical Conditioning, Animal
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
/ genetics
RNA, Messenger
/ metabolism
Reactive Oxygen Species
Transcriptome
Uncoupling Protein 3
/ genetics
Endothelium
Exercise
Metabolic adaptation
Nox4
ROS
Skeletal muscle metabolism
Journal
Molecular metabolism
ISSN: 2212-8778
Titre abrégé: Mol Metab
Pays: Germany
ID NLM: 101605730
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
07
11
2020
revised:
15
12
2020
accepted:
30
12
2020
pubmed:
6
1
2021
medline:
26
10
2021
entrez:
5
1
2021
Statut:
ppublish
Résumé
The immediate signals that couple exercise to metabolic adaptations are incompletely understood. Nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) produces reactive oxygen species (ROS) and plays a significant role in metabolic and vascular adaptation during stress conditions. Our objective was to determine the role of Nox4 in exercise-induced skeletal muscle metabolism. Mice were subjected to acute exercise to assess their immediate responses. mRNA and protein expression responses to Nox4 and hydrogen peroxide (H We identified key exercise-responsive metabolic genes that depend on H We report that H
Identifiants
pubmed: 33400973
pii: S2212-8778(20)30234-9
doi: 10.1016/j.molmet.2020.101160
pmc: PMC7856463
pii:
doi:
Substances chimiques
Fatty Acids
0
Pdk4 protein, mouse
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Ppargc1a protein, mouse
0
Pyruvate Dehydrogenase Acetyl-Transferring Kinase
0
RNA, Messenger
0
Reactive Oxygen Species
0
Ucp3 protein, mouse
0
Uncoupling Protein 3
0
Hydrogen Peroxide
BBX060AN9V
3-Hydroxyacyl CoA Dehydrogenases
EC 1.1.1.-
3-hydroxybutyryl-CoA dehydrogenase
EC 1.1.1.157
NADPH Oxidase 4
EC 1.6.3.-
Nox4 protein, mouse
EC 1.6.3.-
Hexokinase
EC 2.7.1.1
hexokinase 2, mouse
EC 2.7.1.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101160Subventions
Organisme : NIAMS NIH HHS
ID : K01 AR073332
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL098407
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL151626
Pays : United States
Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier GmbH.. All rights reserved.