PICALM mRNA Expression in the Blood of Patients with Neurodegenerative Diseases and Geriatric Depression.
Alzheimer’s disease
blood
gene expression
major depressive disorder
phosphatidylinositol-binding clathrin assembly protein
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2021
2021
Historique:
pubmed:
3
1
2021
medline:
18
9
2021
entrez:
2
1
2021
Statut:
ppublish
Résumé
Phosphatidylinositol-binding clathrin assembly protein (PICALM) is a validated genetic risk factor for late-onset Alzheimer's disease (AD) and is associated with other neurodegenerative diseases. However, PICALM expression in the blood of neurodegenerative diseases remains elusive. This study aimed to assess the usefulness of PICALM expression levels in the blood of patients with AD, Parkinson's disease (PD), dementia with Lewy bodies (DLB), and geriatric major depressive disorder (MDD) as a diagnostic biomarker. In total, 45, 20, 21, and 19 patients with AD, PD, DLB, and geriatric MDD, respectively, and 54 healthy controls (HCs) were enrolled in the study. Expression data from Gene Expression Omnibus database (GSE97760), (GSE133347) and (GSE98793), (GSE48350), and (GSE144459) were used to validate the ability of biomarkers in the blood of patients with AD, PD, geriatric MDD, and a postmortem human AD brain and animal model of AD (3xTg-AD mouse), respectively. PICALM mRNA expression in human blood was significantly increased in patients with AD compared with that in HCs. PICALM mRNA expression and age were negatively correlated only in patients with AD. PICALM mRNA expression in human blood was significantly lower in patients with PD than in HCs. No changes in PICALM mRNA expression were found in patients with DLB and geriatric MDD. PICALM mRNA expression in blood was higher in patients with AD, but lower in patients with PD, which suggests that PICALM mRNA expression in human blood may be a useful biomarker for differentiating neurodegenerative diseases and geriatric MDD.
Sections du résumé
BACKGROUND
Phosphatidylinositol-binding clathrin assembly protein (PICALM) is a validated genetic risk factor for late-onset Alzheimer's disease (AD) and is associated with other neurodegenerative diseases. However, PICALM expression in the blood of neurodegenerative diseases remains elusive.
OBJECTIVE
This study aimed to assess the usefulness of PICALM expression levels in the blood of patients with AD, Parkinson's disease (PD), dementia with Lewy bodies (DLB), and geriatric major depressive disorder (MDD) as a diagnostic biomarker.
METHODS
In total, 45, 20, 21, and 19 patients with AD, PD, DLB, and geriatric MDD, respectively, and 54 healthy controls (HCs) were enrolled in the study. Expression data from Gene Expression Omnibus database (GSE97760), (GSE133347) and (GSE98793), (GSE48350), and (GSE144459) were used to validate the ability of biomarkers in the blood of patients with AD, PD, geriatric MDD, and a postmortem human AD brain and animal model of AD (3xTg-AD mouse), respectively.
RESULTS
PICALM mRNA expression in human blood was significantly increased in patients with AD compared with that in HCs. PICALM mRNA expression and age were negatively correlated only in patients with AD. PICALM mRNA expression in human blood was significantly lower in patients with PD than in HCs. No changes in PICALM mRNA expression were found in patients with DLB and geriatric MDD.
CONCLUSION
PICALM mRNA expression in blood was higher in patients with AD, but lower in patients with PD, which suggests that PICALM mRNA expression in human blood may be a useful biomarker for differentiating neurodegenerative diseases and geriatric MDD.
Identifiants
pubmed: 33386803
pii: JAD201046
doi: 10.3233/JAD-201046
pmc: PMC7990403
doi:
Substances chimiques
Monomeric Clathrin Assembly Proteins
0
PICALM protein, human
0
RNA, Messenger
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1055-1062Références
Neurology. 2017 Jul 4;89(1):88-100
pubmed: 28592453
J Psychiatr Res. 2018 Dec;107:79-85
pubmed: 30366284
J Mol Neurosci. 2014 Dec;54(4):774-9
pubmed: 25022884
J Alzheimers Dis. 2015;43(1):93-108
pubmed: 25079797
J Alzheimers Dis. 2017;57(1):171-181
pubmed: 28222527
Dement Geriatr Cogn Disord. 2016;41(5-6):334-47
pubmed: 27414430
J Alzheimers Dis. 2017;60(3):1107-1117
pubmed: 28984592
J Alzheimers Dis. 2018;65(1):283-292
pubmed: 30040717
J Affect Disord. 2020 Jun 15;271:185-192
pubmed: 32479315
J Psychiatr Res. 2017 Sep;92:74-80
pubmed: 28412600
Acta Neuropathol. 2020 Oct;140(4):449-461
pubmed: 32749525
Psychiatry Clin Neurosci. 2018 Mar;72(3):152-159
pubmed: 29315976
J Parkinsons Dis. 2016;6(1):119-24
pubmed: 26889634
PLoS One. 2015 Sep 02;10(9):e0136835
pubmed: 26332043
Int J Neurosci. 2012 Oct;122(10):502-605
pubmed: 22715855
Nat Commun. 2016 Jun 21;7:11934
pubmed: 27327500
Neurobiol Dis. 2016 Oct;94:32-43
pubmed: 27260836
Neurobiol Aging. 2019 Dec;84:243.e1-243.e9
pubmed: 30979435
Mol Neurobiol. 2020 Dec;57(12):4941-4951
pubmed: 32816243
J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52
pubmed: 2841426
Cell. 2015 Nov 19;163(5):1064-1078
pubmed: 26590417
Nat Neurosci. 2015 Jul;18(7):978-87
pubmed: 26005850
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15605-10
pubmed: 18832152
PLoS One. 2011;6(8):e24211
pubmed: 21912625
JAMA Netw Open. 2019 Aug 2;2(8):e198964
pubmed: 31397865
Lancet Neurol. 2015 Apr;14(4):388-405
pubmed: 25792098
Psychiatry Clin Neurosci. 2018 Mar;72(3):160-167
pubmed: 29112298
Acta Neuropathol. 2020 Apr;139(4):773-789
pubmed: 31925534
Lancet. 2020 Aug 8;396(10248):413-446
pubmed: 32738937
Neuromolecular Med. 2017 Sep;19(2-3):293-299
pubmed: 28567584
BMC Immunol. 2007 Sep 12;8:20
pubmed: 17850649
Psychogeriatrics. 2011 Sep;11(3):157-65
pubmed: 21951956
J Psychiatr Res. 2015 Jul-Aug;66-67:1-6
pubmed: 25943949
Biol Psychiatry. 2018 Jan 1;83(1):70-80
pubmed: 28688579
Nat Rev Dis Primers. 2015 Oct 15;1:15056
pubmed: 27188934
J Alzheimers Dis. 2017;58(3):687-694
pubmed: 28482637
Nat Genet. 2019 Mar;51(3):414-430
pubmed: 30820047
J Alzheimers Dis. 2017;59(3):975-985
pubmed: 28697559
Transl Psychiatry. 2020 Mar 9;10(1):88
pubmed: 32152295
J Appl Physiol (1985). 2015 Feb 1;118(3):386-94
pubmed: 25429098
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Neurobiol Aging. 2017 Oct;58:225-237
pubmed: 28716532
J Alzheimers Dis. 2018;64(4):1275-1284
pubmed: 30010135
Neurology. 2016 Jul 26;87(4):426-37
pubmed: 27358339
J Alzheimers Dis. 2015;45(3):907-19
pubmed: 25633681