Invasive fungal infection before and after liver transplantation.
Acute liver failure
Acute-on-chronic liver failure
Candidemia
Cirrhosis
Invasive fungal infection
Sepsis
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
21 Dec 2020
21 Dec 2020
Historique:
received:
18
10
2020
revised:
15
11
2020
accepted:
29
11
2020
entrez:
1
1
2021
pubmed:
2
1
2021
medline:
15
5
2021
Statut:
ppublish
Résumé
Invasive infections are a major complication before liver transplantation (LT) and in the early phase after surgery. There has been an increasing prevalence of invasive fungal disease (IFD), especially among the sickest patients with decompensated cirrhosis and acute-on-chronic liver failure, who suffer from a profound state of immune dysfunction and receive intensive care management. In such patients, who are listed for LT, development of an IFD often worsens hepatic and extra-hepatic organ dysfunction, requiring a careful evaluation before surgery. In the post-transplant setting, the burden of IFD has been reduced after the clinical advent of antifungal prophylaxis, even if several major issues still remain, such as duration, target population and drug type(s). Nevertheless, the development of IFD in the early phase after surgery significantly impairs graft and patient survival. This review outlines presentation, prophylactic and therapeutic strategies, and outcomes of IFD in LT candidates and recipients, providing specific considerations for clinical practice.
Identifiants
pubmed: 33384549
doi: 10.3748/wjg.v26.i47.7485
pmc: PMC7754548
doi:
Substances chimiques
Antifungal Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
7485-7496Informations de copyright
©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The Authors have nothing to disclose regarding this manuscript.
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