Beyond Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice.

Immunology Space Sciences

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
18 Dec 2020
Historique:
received: 15 06 2020
revised: 16 10 2020
accepted: 26 10 2020
entrez: 30 12 2020
pubmed: 31 12 2020
medline: 31 12 2020
Statut: epublish

Résumé

Spaceflight missions can cause immune system dysfunction in astronauts with little understanding of immune outcomes in deep space. This study assessed immune responses in mice following ground-based, simulated deep spaceflight conditions, compared with data from astronauts on International Space Station missions. For ground studies, we simulated microgravity using the hindlimb unloaded mouse model alone or in combination with acute simulated galactic cosmic rays or solar particle events irradiation. Immune profiling results revealed unique immune diversity following each experimental condition, suggesting each stressor results in distinct circulating immune responses, with clear consequences for deep spaceflight. Circulating plasma microRNA sequence analysis revealed involvement in immune system dysregulation. Furthermore, a large astronaut cohort showed elevated inflammation during low-Earth orbit missions, thereby supporting our simulated ground experiments in mice. Herein, circulating immune biomarkers are defined by distinct deep space irradiation types coupled to simulated microgravity and could be targets for future space health initiatives.

Identifiants

pubmed: 33376970
doi: 10.1016/j.isci.2020.101747
pii: S2589-0042(20)30944-5
pmc: PMC7756144
doi:

Types de publication

Journal Article

Langues

eng

Pagination

101747

Informations de copyright

© 2020 The Author(s).

Déclaration de conflit d'intérêts

All authors declare no competing interests.

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Auteurs

Amber M Paul (AM)

Universities Space Research Association, Columbia, MD 21046, USA.
Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94043, USA.

Margareth Cheng-Campbell (M)

Department of Biomedical Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

Elizabeth A Blaber (EA)

Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94043, USA.
Department of Biomedical Engineering, Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

Sulekha Anand (S)

Department of Biological Sciences, San Jose State University, San Jose, CA 95112, USA.

Sharmila Bhattacharya (S)

Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94043, USA.

Sara R Zwart (SR)

Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX 77555, USA.

Brian E Crucian (BE)

NASA Johnson Space Center, Houston, TX 77058, USA.

Scott M Smith (SM)

NASA Johnson Space Center, Houston, TX 77058, USA.

Robert Meller (R)

Department of Neurobiology/Pharmacology, Morehouse School of Medicine, Atlanta, GA 30310, USA.

Peter Grabham (P)

Center for Radiological Research, Columbia University, New York, NY 10027, USA.

Afshin Beheshti (A)

KBR, Space Biosciences Division, NASA Ames Research Center, Moffett Field, CA 94043, USA.

Classifications MeSH