RTEL1 Regulates G4/R-Loops to Avert Replication-Transcription Collisions.
G-quadruplexes
G4-DNA structures
R-loops
RTEL1
genome instability
replication stress
transcription
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
22 12 2020
22 12 2020
Historique:
received:
24
06
2020
revised:
29
10
2020
accepted:
01
12
2020
entrez:
28
12
2020
pubmed:
29
12
2020
medline:
22
12
2021
Statut:
ppublish
Résumé
Regulator of telomere length 1 (RTEL1) is an essential helicase that maintains telomere integrity and facilitates DNA replication. The source of replication stress in Rtel1-deficient cells remains unclear. Here, we report that loss of RTEL1 confers extensive transcriptional changes independent of its roles at telomeres. The majority of affected genes in Rtel1
Identifiants
pubmed: 33357438
pii: S2211-1247(20)31535-7
doi: 10.1016/j.celrep.2020.108546
pmc: PMC7773548
pii:
doi:
Substances chimiques
DNA
9007-49-2
RTEL1 protein, human
EC 3.6.1.-
DNA Helicases
EC 3.6.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108546Subventions
Organisme : Cancer Research UK
ID : FC0010048
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC0010048
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC0010048
Pays : United Kingdom
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests S.J.B. is also scientific co-founder and VP Science Strategy at Artios Pharma, Babraham Research Campus, Cambridge, UK.
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