Estimating prevalence of subjective cognitive decline in and across international cohort studies of aging: a COSMIC study.

Aging Cognitive Dysfunction / epidemiology Cohort Studies Female Humans Male Middle Aged Neuropsychological Tests Prevalence
Cohort study Data harmonization Epidemiology Individual participant data Prevalence Subjective cognitive decline

Journal

Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643

Informations de publication

Date de publication:
18 12 2020
Historique:
received: 03 07 2020
accepted: 26 11 2020
entrez: 19 12 2020
pubmed: 20 12 2020
medline: 25 6 2021
Statut: epublish

Résumé

Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts. We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence. The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades. SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.

Sections du résumé

BACKGROUND
Subjective cognitive decline (SCD) is recognized as a risk stage for Alzheimer's disease (AD) and other dementias, but its prevalence is not well known. We aimed to use uniform criteria to better estimate SCD prevalence across international cohorts.
METHODS
We combined individual participant data for 16 cohorts from 15 countries (members of the COSMIC consortium) and used qualitative and quantitative (Item Response Theory/IRT) harmonization techniques to estimate SCD prevalence.
RESULTS
The sample comprised 39,387 cognitively unimpaired individuals above age 60. The prevalence of SCD across studies was around one quarter with both qualitative harmonization/QH (23.8%, 95%CI = 23.3-24.4%) and IRT (25.6%, 95%CI = 25.1-26.1%); however, prevalence estimates varied largely between studies (QH 6.1%, 95%CI = 5.1-7.0%, to 52.7%, 95%CI = 47.4-58.0%; IRT: 7.8%, 95%CI = 6.8-8.9%, to 52.7%, 95%CI = 47.4-58.0%). Across studies, SCD prevalence was higher in men than women, in lower levels of education, in Asian and Black African people compared to White people, in lower- and middle-income countries compared to high-income countries, and in studies conducted in later decades.
CONCLUSIONS
SCD is frequent in old age. Having a quarter of older individuals with SCD warrants further investigation of its significance, as a risk stage for AD and other dementias, and of ways to help individuals with SCD who seek medical advice. Moreover, a standardized instrument to measure SCD is needed to overcome the measurement variability currently dominant in the field.

Identifiants

DOI: 10.1186/s13195-020-00734-y PMID: 33339532 PMC: PMC7749505
pubmed: 33339532
doi: 10.1186/s13195-020-00734-y
pii: 10.1186/s13195-020-00734-y
pmc: PMC7749505
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

167

Subventions

Organisme : Medical Research Council
ID : G0601022
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : RF1 AG057531
Pays : United States
Organisme : NIA NIH HHS
ID : RF1AG057531
Pays : United States

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Auteurs

Susanne Röhr (S)

Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany. susanne.roehr@medizin.uni-leipzig.de.
Global Brain Health Institute (GBHI), Trinity College Dublin, Dublin, Ireland. susanne.roehr@medizin.uni-leipzig.de.
ORCID: 0000-0001-9385-0669

Alexander Pabst (A)

Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany.

Steffi G Riedel-Heller (SG)

Institute of Social Medicine, Occupational Health and Public Health (ISAP), Medical Faculty, University of Leipzig, Philipp-Rosenthal-Straße 55, 04103, Leipzig, Germany.

Frank Jessen (F)

Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

Yuda Turana (Y)

Department of Neurology, School of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.

Yvonne S Handajani (YS)

Center for Health Research, School of Medicine, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia.

Carol Brayne (C)

Cambridge Public Health, Cambridge University, Cambridge, UK.

Fiona E Matthews (FE)

MRC Biostatistics Unit, Institute of Public Health, Cambridge University, Cambridge, UK.
Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Blossom C M Stephan (BCM)

Institute of Health and Society, Newcastle University, Newcastle upon Tyne, UK.

Richard B Lipton (RB)

Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.
Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.
Department of Psychiatry and Behavioral Medicine, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.

Mindy J Katz (MJ)

Saul R. Korey Department of Neurology, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.

Cuiling Wang (C)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, New York, NY, USA.

Maëlenn Guerchet (M)

INSERM, U1094, Tropical Neuroepidemiology, Limoges, France.
Univ. Limoges, U1094, Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.
IRD, Associated Unit, Tropical Neuroepidemiology, Limoges, France.

Pierre-Marie Preux (PM)

INSERM, U1094, Tropical Neuroepidemiology, Limoges, France.
Univ. Limoges, U1094, Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.
CHU, Department of Medical Information & Evaluation, Clinical Research and Biostatistic Unit, Limoges, France.

Pascal Mbelesso (P)

INSERM, U1094, Tropical Neuroepidemiology, Limoges, France.
Univ. Limoges, U1094, Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.
Department of Neurology, Amitié Hospital, Bangui, Central African Republic.

Karen Ritchie (K)

INSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier, Montpellier, France.
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Marie-Laure Ancelin (ML)

INSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier, Montpellier, France.

Isabelle Carrière (I)

INSERM U1061 Neuropsychiatry: Epidemiological and Clinical Research, La Colombière Hospital, Montpellier Cedex 5, Université de Montpellier, Montpellier, France.

Antonio Guaita (A)

Golgi Cenci Foundation, Corso San Martino 10, 20081, Abbiategrasso, Italy.

Annalisa Davin (A)

Golgi Cenci Foundation, Corso San Martino 10, 20081, Abbiategrasso, Italy.

Roberta Vaccaro (R)

Golgi Cenci Foundation, Corso San Martino 10, 20081, Abbiategrasso, Italy.

Ki Woong Kim (KW)

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.

Ji Won Han (JW)

Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.

Seung Wan Suh (SW)

Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.

Suzana Shahar (S)

Centre of Healthy Aging and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Normah C Din (NC)

Centre for Rehabilitation Science and Special Needs, Faculty of Health Science, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.

Divya Vanoh (D)

School of Health Science, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.

Martin van Boxtel (M)

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.

Sebastian Köhler (S)

Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Center (MUMC), Maastricht, The Netherlands.

Mary Ganguli (M)

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.

Erin P Jacobsen (EP)

Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Beth E Snitz (BE)

Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.

Kaarin J Anstey (KJ)

Ageing Futures Institute, University of New South Wales, Sydney, NSW, Australia.
Neuroscience Research Australia, Sydney, NSW, Australia.
Centre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, Australian National University, Canberra, ACT, Australia.

Nicolas Cherbuin (N)

Centre for Research on Ageing, Health and Wellbeing, College of Health and Medicine, Australian National University, Canberra, ACT, Australia.

Shuzo Kumagai (S)

Center for Health Science and Counseling, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, 819-0395, Japan.

Sanmei Chen (S)

Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

Kenji Narazaki (K)

Faculty of Socio-Environmental Studies, Department of Socio-Environmental Studies, Fukuoka Institute of Technology, 3-30-1 Wajiro-higashi, Higashi-ku, Fukuoka, 811-0295, Japan.

Tze Pin Ng (TP)

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Qi Gao (Q)

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Xinyi Gwee (X)

Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Henry Brodaty (H)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
Dementia Collaborative Research Centre, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.

Nicole A Kochan (NA)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.

Julian Trollor (J)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
Department of Developmental Disability Neuropsychiatry, University of New South Wales Sydney, Sydney, Australia.

Antonio Lobo (A)

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain.
Department of Medicine and Psychiatry, Universidad de Zaragoza and Instituto de Investigación Sanitaria Aragón, Zaragoza, Spain.

Raúl López-Antón (R)

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain.
Department of Psychology and Sociology, Universidad de Zaragoza, Zaragoza, Spain.

Javier Santabárbara (J)

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Ministry of Science and Innovation, Madrid, Spain.
Department of Microbiology, Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain.

John D Crawford (JD)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.

Darren M Lipnicki (DM)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.

Perminder S Sachdev (PS)

Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.
Dementia Collaborative Research Centre, School of Psychiatry, University of New South Wales Sydney, Sydney, Australia.

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Classifications MeSH

Recherchemedicale.com › Phénomènes physiologiques › Croissance et développement › Vieillissement › Estimating prevalence of subjective cognitive...
Recherchemedicale.com › Troubles mentaux › Troubles neurocognitifs › Troubles de la cognition › Dysfonctionnement cognitif › Estimating prevalence of subjective cognitive...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Estimating prevalence of subjective cognitive...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Estimating prevalence of subjective cognitive...
Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Estimating prevalence of subjective cognitive...
Recherchemedicale.com › Disciplines et activités comportementales › Tests psychologiques › Tests neuropsychologiques › Estimating prevalence of subjective cognitive...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Estimating prevalence of subjective cognitive...