Synthesis, Characterization, and
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
10 Dec 2020
10 Dec 2020
Historique:
received:
26
06
2020
accepted:
23
10
2020
entrez:
18
12
2020
pubmed:
19
12
2020
medline:
19
12
2020
Statut:
epublish
Résumé
Ecto-5'-nucleotidase (ecto-5'-NT, CD73) inhibitors are promising drug candidates for cancer therapy. Traditional efforts used to inhibit the ecto-5'-nucleotidase have involved antibody therapy or development of small molecule inhibitors that can mimic the acidic and ionizable structure of adenosine 5'-monophosphate (AMP). Herein, we report an efficient, environment friendly route for the synthesis of non-nucleotide based small molecules, i.e., substituted spirooxindole derivatives
Identifiants
pubmed: 33335662
doi: 10.1021/acsmedchemlett.0c00343
pmc: PMC7734640
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2397-2405Informations de copyright
© 2020 The Authors. Published by American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
Références
Bioorg Med Chem Lett. 2007 Aug 1;17(15):4297-302
pubmed: 17532631
Cancer Res. 2010 Aug 15;70(16):6407-11
pubmed: 20682793
Eur J Med Chem. 2013;70:685-91
pubmed: 24215819
J Med Chem. 2015 Aug 13;58(15):6248-63
pubmed: 26147331
Med Res Rev. 2014 Jul;34(4):703-43
pubmed: 24115166
R Soc Open Sci. 2018 Sep 12;5(9):180837
pubmed: 30839737
J Med Chem. 2005 Nov 3;48(22):6843-54
pubmed: 16250643
Eur J Biochem. 1990 Aug 17;191(3):563-9
pubmed: 2129526
Bioorg Chem. 2020 Jul;100:103827
pubmed: 32402802
Int J Cancer. 1996 Nov 15;68(4):493-500
pubmed: 8945621
Med Chem. 2012 Nov;8(6):1133-9
pubmed: 22741787
Bioorg Med Chem Lett. 2007 Mar 1;17(5):1243-5
pubmed: 17234412
J Med Chem. 2010 Mar 11;53(5):2076-86
pubmed: 20146483
Bioorg Med Chem Lett. 2001 Mar 26;11(6):781-4
pubmed: 11277519
Anal Biochem. 2008 Feb 1;373(1):129-40
pubmed: 17980347
J Biol Chem. 1990 Feb 5;265(4):2178-83
pubmed: 2298743
Anal Biochem. 2014 Feb 1;446:53-8
pubmed: 24144488
Bioorg Med Chem. 2008 Aug 1;16(15):7167-76
pubmed: 18625560
J Med Chem. 2020 Oct 22;63(20):11448-11468
pubmed: 32614585
Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1547-52
pubmed: 20080644
Angew Chem Int Ed Engl. 2003 Feb 10;42(6):694-6
pubmed: 12575009
J Med Chem. 2019 Apr 11;62(7):3677-3695
pubmed: 30895781
Crit Rev Biochem Mol Biol. 2014 Nov-Dec;49(6):473-97
pubmed: 25418535
Chem Biol Drug Des. 2017 Mar;89(3):365-370
pubmed: 27589035
Bioorg Med Chem Lett. 2009 Aug 15;19(16):4566-9
pubmed: 19615897
Structure. 2012 Dec 5;20(12):2161-73
pubmed: 23142347
Protein Sci. 1994 Feb;3(2):356-8
pubmed: 8003970
Eur J Biochem. 1991 Dec 18;202(3):855-61
pubmed: 1765099
Pharmacol Ther. 2000 Aug-Sep;87(2-3):161-73
pubmed: 11007998
J Immunol. 2008 May 1;180(9):6288-96
pubmed: 18424752
Bioorg Med Chem. 2009 Jul 1;17(13):4763-72
pubmed: 19447039
J Med Chem. 2020 Apr 23;63(8):3935-3955
pubmed: 32212732
Org Biomol Chem. 2018 Jan 31;16(5):717-732
pubmed: 29303198
Eur J Immunol. 2011 May;41(5):1231-41
pubmed: 21469131
Biochem J. 1992 Jul 15;285 ( Pt 2):345-65
pubmed: 1637327
Biochem J. 1987 Aug 1;245(3):805-10
pubmed: 2822031
Chem Cent J. 2011 Jul 26;5(1):45
pubmed: 21791053