Exacerbation of Allergic Airway Inflammation in Mice Lacking ECTO-5'-Nucleotidase (CD73).
CD73
adenosine
airways
allergy
ecto-5′-nucleotidase
inflammation
ovalbumin
sensitization
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
07
2020
accepted:
20
10
2020
entrez:
17
12
2020
pubmed:
18
12
2020
medline:
18
12
2020
Statut:
epublish
Résumé
The airways are a target tissue of type I allergies and atopy is the main etiological factor of bronchial asthma. A predisposition to allergy and individual response to allergens are dependent upon environmental and host factors. Early studies performed to clarify the role of extracellular adenosine in the airways highlighted the importance of adenosine-generating enzymes CD73, together with CD39, as an innate protection system against lung injury. In experimental animals, deletion of CD73 has been associated with immune and autoimmune diseases. Our experiments have been performed to investigate the role of CD73 in the assessment of allergic airway inflammation following sensitization. We found that in CD73
Identifiants
pubmed: 33328996
doi: 10.3389/fphar.2020.589343
pii: 589343
pmc: PMC7734328
doi:
Types de publication
Journal Article
Langues
eng
Pagination
589343Informations de copyright
Copyright © 2020 Caiazzo, Cerqua, Riemma, Turiello, Ialenti, Schrader, Fiume, Caiazza, Roviezzo, Morello and Cicala.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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