Absence of latitudinal gradient in oligoclonal bands prevalence in Argentina.
Clinically isolated syndrome
Epidemiology
Latitudinal gradient
Multiple sclerosis
Oligoclonal bands
Radiologically isolated syndrome
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
22
09
2020
revised:
06
10
2020
accepted:
12
10
2020
pubmed:
11
12
2020
medline:
15
5
2021
entrez:
10
12
2020
Statut:
ppublish
Résumé
Like MS prevalence, oligoclonal bands (OCB) frequency seems to follow a latitudinal gradient. Argentina is extensive, latitude-wise, and previous studies have not found an MS prevalence latitudinal gradient. Our aim is to describe OCB prevalence in MS, clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) patients included in the Argentinean MS and NMOSD registry (RelevarEM) and to investigate if it follows a latitudinal gradient. For each province, an average latitude was calculated, and OCB frequency was investigated. Multivariate logistical regression analysis and linear correlation were performed. Statistical analysis was repeated after excluding patients from centers using isoelectric focusing (IEF) in less than 95% of patients (CwIEF<95). We included 2866 patients. OCB where positive in 73.9% of patients. No association or correlation were found between OCB and latitude of residence, even after excluding patients from (CwIEF<95). OCB positivity does not follow a latitudinal gradient in Argentina. Also, OCB positivity is lower than described in other world regions.
Sections du résumé
BACKGROUND
BACKGROUND
Like MS prevalence, oligoclonal bands (OCB) frequency seems to follow a latitudinal gradient. Argentina is extensive, latitude-wise, and previous studies have not found an MS prevalence latitudinal gradient. Our aim is to describe OCB prevalence in MS, clinically isolated syndrome (CIS) and radiologically isolated syndrome (RIS) patients included in the Argentinean MS and NMOSD registry (RelevarEM) and to investigate if it follows a latitudinal gradient.
METHODS
METHODS
For each province, an average latitude was calculated, and OCB frequency was investigated. Multivariate logistical regression analysis and linear correlation were performed. Statistical analysis was repeated after excluding patients from centers using isoelectric focusing (IEF) in less than 95% of patients (CwIEF<95).
RESULTS
RESULTS
We included 2866 patients. OCB where positive in 73.9% of patients. No association or correlation were found between OCB and latitude of residence, even after excluding patients from (CwIEF<95).
CONCLUSION
CONCLUSIONS
OCB positivity does not follow a latitudinal gradient in Argentina. Also, OCB positivity is lower than described in other world regions.
Identifiants
pubmed: 33296978
pii: S2211-0348(20)30656-8
doi: 10.1016/j.msard.2020.102582
pii:
doi:
Substances chimiques
Oligoclonal Bands
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
102582Informations de copyright
Copyright © 2020. Published by Elsevier B.V.