Testosterone Use in Adolescent Males: Current Practice and Unmet Needs.
adolescent male
hypogonadism
puberty
testosterone
testosterone therapy
Journal
Journal of the Endocrine Society
ISSN: 2472-1972
Titre abrégé: J Endocr Soc
Pays: United States
ID NLM: 101697997
Informations de publication
Date de publication:
01 Jan 2021
01 Jan 2021
Historique:
received:
14
08
2020
entrez:
9
12
2020
pubmed:
10
12
2020
medline:
10
12
2020
Statut:
epublish
Résumé
Testosterone replacement therapy (TRT) is routinely prescribed in adolescent males with constitutional delay of growth and puberty (CDGP) or hypogonadism. With many new testosterone (T) formulations entering the market targeted for adults, we review current evidence and TRT options for adolescents and identify areas of unmet needs. We searched PubMed for articles (in English) on testosterone therapy, androgens, adolescence, and puberty in humans. The results indicate that short-term use of T enanthate (TE) or oral T undecanoate is safe and effective in inducing puberty and increasing growth in males with CDGP. Reassuring evidence is emerging on the use of transdermal T to induce and maintain puberty. The long-term safety and efficacy of TRT for puberty completion and maintenance have not been established. Current TRT regimens are based on consensus and expert opinion, but evidence-based guidelines are lacking. Limited guidance exists on when and how T should be administered and optimal strategies for monitoring therapy once it is initiated. Only TE and T pellets are US Food and Drug Administration approved for use in adolescent males in the United States. Despite the introduction of a wide variety of new T formulations, they are designed for adults, and their metered doses are difficult to titrate in adolescents. In conclusion, TRT in adolescent males is hindered by lack of long-term safety and efficacy data and limited options approved for use in this population. Additional research is needed to identify the route, dose, duration, and optimal timing for TRT in adolescents requiring androgen therapy.
Identifiants
pubmed: 33294762
doi: 10.1210/jendso/bvaa161
pii: bvaa161
pmc: PMC7705876
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
bvaa161Informations de copyright
© The Author(s) 2020. Published by Oxford University Press on behalf of the Endocrine Society.
Références
Sci Rep. 2015 Jun 18;5:11208
pubmed: 26084728
J Pediatr Endocrinol Metab. 1996 Sep-Oct;9(5):511-7
pubmed: 8961126
Horm Res Paediatr. 2011;75(1):8-13
pubmed: 20664179
Pediatr Endocrinol Rev. 2005 Mar;2(3):383-90
pubmed: 16429115
Endocr Pract. 2013 Nov-Dec;19(6):968-71
pubmed: 23807524
J Am Acad Child Adolesc Psychiatry. 2004 Jun;43(6):718-26
pubmed: 15167088
Horm Res Paediatr. 2018;90(2):123-127
pubmed: 30021202
J Clin Endocrinol Metab. 1998 Dec;83(12):4280-3
pubmed: 9851764
J Clin Endocrinol Metab. 2012 Sep;97(9):3056-67
pubmed: 22723321
Br J Haematol. 2009 Sep;146(5):546-56
pubmed: 19604241
Lancet Neurol. 2018 Mar;17(3):251-267
pubmed: 29395989
J Pediatr. 1982 Apr;100(4):633-7
pubmed: 7062217
J Endocr Soc. 2019 Sep 26;3(12):2276-2285
pubmed: 31737857
Arch Dis Child. 1997 Jun;76(6):495-9
pubmed: 9245845
Expert Opin Pharmacother. 2010 Aug;11(12):2095-106
pubmed: 20642374
J Clin Endocrinol Metab. 1992 Jul;75(1):37-44
pubmed: 1619029
Psychoneuroendocrinology. 2016 Jan;63:109-18
pubmed: 26431805
J Clin Endocrinol Metab. 2020 Mar 1;105(3):
pubmed: 31511863
Pediatrics. 1982 Jun;69(6):681-7
pubmed: 7043385
Pediatr Clin North Am. 1980 Feb;27(1):71-7
pubmed: 6966388
J Clin Endocrinol Metab. 2018 Aug 1;103(8):2761-2784
pubmed: 29982476
J Sex Med. 2017 Dec;14(12):1504-1523
pubmed: 29198507
J Clin Endocrinol Metab. 2019 Oct 1;104(10):4578-4586
pubmed: 31194243
J Clin Endocrinol Metab. 2017 Jul 1;102(7):2349-2355
pubmed: 28379417
Eur J Pediatr. 1992 Jan;151(1):15-8
pubmed: 1728537
J Androl. 2012 Jul-Aug;33(4):570-3
pubmed: 21940986
Metabolism. 1995 Aug;44(8):1013-5
pubmed: 7637642
Clin Endocrinol (Oxf). 1992 Sep;37(3):207-13
pubmed: 1424202
Transl Androl Urol. 2016 Dec;5(6):834-843
pubmed: 28078214
J Pediatr Endocrinol Metab. 1995 Apr-Jun;8(2):117-22
pubmed: 7584705
J Pediatr Endocrinol Metab. 1997 Jul-Aug;10(4):395-400
pubmed: 9364366
Am J Dis Child. 1989 Jan;143(1):116-20
pubmed: 2910039
J Bone Miner Res. 2006 May;21(5):790-5
pubmed: 16734395
J Urol. 2014 May;191(5 Suppl):1527-31
pubmed: 24679877
Best Pract Res Clin Endocrinol Metab. 2002 Mar;16(1):73-90
pubmed: 11987900
Metabolism. 2003 Aug;52(8):964-9
pubmed: 12898459
Hum Reprod. 2017 Jan;32(1):147-153
pubmed: 27927844
Appl Clin Genet. 2019 Oct 23;12:191-202
pubmed: 31695472
J Clin Endocrinol Metab. 2004 Feb;89(2):681-7
pubmed: 14764781
J Pediatr Endocrinol Metab. 2017 Nov 27;30(12):1285-1291
pubmed: 29176021
J Clin Endocrinol Metab. 2013 Jan;98(1):20-30
pubmed: 23118429
J Clin Endocrinol Metab. 1989 Oct;69(4):776-83
pubmed: 2674186
Endocr Dev. 2016;29:185-97
pubmed: 26680579
J Pediatr Endocrinol Metab. 2004 Jul;17(7):941-50
pubmed: 15301041
Pediatr Neurosurg. 2004 May-Jun;40(3):112-9
pubmed: 15367800
J Pediatr Endocrinol Metab. 2017 Jan 1;30(1):105-109
pubmed: 27997352
Best Pract Res Clin Endocrinol Metab. 2019 Jun;33(3):101275
pubmed: 31047817
Horm Res Paediatr. 2019;92(4):215-228
pubmed: 31851967
Am J Dis Child. 1988 Dec;142(12):1345-8
pubmed: 3195533
Pediatr Endocrinol Rev. 2010 Dec;8 Suppl 1:145-50
pubmed: 21217606
Clin Endocrinol (Oxf). 1999 Oct;51(4):469-71
pubmed: 10583314
Pharmacoepidemiol Drug Saf. 2017 Feb;26(2):119-126
pubmed: 27528454
Pediatr Int. 2001 Apr;43(2):134-6
pubmed: 11285063
J Clin Endocrinol Metab. 2007 Sep;92(9):3476-82
pubmed: 17579201
J Urol. 2004 Jul;172(1):319-24
pubmed: 15201804
Arch Dis Child. 1994 Oct;71(4):315-7
pubmed: 7979523
Arch Dis Child. 1998 Apr;78(4):397
pubmed: 9623416
Endocr Rev. 2018 Aug 1;39(4):389-423
pubmed: 29438472
N Engl J Med. 2012 Feb 2;366(5):443-53
pubmed: 22296078
J Clin Endocrinol Metab. 2003 Feb;88(2):622-6
pubmed: 12574191
Arch Dis Child. 2016 Aug;101(8):767-71
pubmed: 27190100
Am J Dis Child. 1988 Jan;142(1):96-9
pubmed: 3341306
Psychoneuroendocrinology. 2017 Feb;76:206-217
pubmed: 27984812
Pharm Res. 2006 Jun;23(6):1117-32
pubmed: 16755346
J Adolesc Health. 2014 Jan;54(1):20-5
pubmed: 24035132
Clin Endocrinol (Oxf). 2007 Apr;66(4):579-85
pubmed: 17371478
J Bone Miner Res. 2018 Mar;33(3):430-436
pubmed: 29068475
J Clin Endocrinol Metab. 1980 Dec;51(6):1335-9
pubmed: 6777395
J Clin Endocrinol Metab. 2015 Apr;100(4):1376-85
pubmed: 25594861
Pediatrics. 2017 Jun;139(6):
pubmed: 28562264
J Clin Endocrinol Metab. 2010 Dec;95(12):5225-32
pubmed: 20826577
J Androl. 2009 Sep-Oct;30(5):602-13
pubmed: 19342702
J Pediatr Endocrinol Metab. 2006 Jan;19(1):55-64
pubmed: 16509529
Best Pract Res Clin Endocrinol Metab. 2015 Jun;29(3):367-83
pubmed: 26051297
Med Sci Monit. 2010 Nov;16(11):CR511-7
pubmed: 20980953
Endocr Rev. 2020 Jun 1;41(3):
pubmed: 32115641
Andrology. 2016 Jan;4(1):46-54
pubmed: 26695758
J Urol. 2018 Aug;200(2):423-432
pubmed: 29601923
J Clin Endocrinol Metab. 2018 May 1;103(5):1715-1744
pubmed: 29562364
Front Endocrinol (Lausanne). 2019 Jul 25;10:345
pubmed: 31402895
Neuromuscul Disord. 2012 Dec;22(12):1046-56
pubmed: 22967789
J Clin Oncol. 2019 Apr 10;37(11):893-902
pubmed: 30811296
AACE Clin Case Rep. 2016 Fall;2(4):e351-e357
pubmed: 28868357
Horm Res Paediatr. 2010;74(4):292-6
pubmed: 20938205
Arch Dis Child. 1990 Oct;65(10):1109-12
pubmed: 2248500
Int J Epidemiol. 2016 Aug;45(4):1113-1124
pubmed: 27401728
Ann Pediatr Endocrinol Metab. 2018 Jun;23(2):57-61
pubmed: 29969875
J Clin Endocrinol Metab. 2006 Aug;91(8):3017-23
pubmed: 16735493
J Clin Endocrinol Metab. 1996 Mar;81(3):1152-5
pubmed: 8772591
Horm Res. 2003;59(6):270-5
pubmed: 12784090
J Cyst Fibros. 2019 Oct;18 Suppl 2:S105-S110
pubmed: 31679721
Int J Radiat Oncol Biol Phys. 2002 Sep 1;54(1):45-50
pubmed: 12182973
Horm Res Paediatr. 2018;90(5):326-331
pubmed: 30695784
J Clin Endocrinol Metab. 2004 Sep;89(9):4306-11
pubmed: 15356025
Clin Endocrinol (Oxf). 2019 Jul;91(1):3-9
pubmed: 30903626
Nat Rev Endocrinol. 2015 Sep;11(9):547-64
pubmed: 26194704
Dev Psychopathol. 2009 Spring;21(2):593-620
pubmed: 19338700
Arch Dis Child. 1995 Aug;73(2):131-5
pubmed: 7574856
Clin Endocrinol (Oxf). 2003 Mar;58(3):267-72
pubmed: 12608930
Asian J Androl. 2014 Mar-Apr;16(2):161-8
pubmed: 24435052
Expert Opin Pharmacother. 2005 Jul;6(8):1319-36
pubmed: 16013983
Nat Rev Endocrinol. 2016 Jun;12(6):319-36
pubmed: 27032982
J Endocrinol Invest. 2018 Feb;41(2):259-263
pubmed: 28695484
Endocr Rev. 2019 Apr 1;40(2):669-710
pubmed: 30698671
J Pediatr Endocrinol Metab. 1998;11 Suppl 3:891-900
pubmed: 10091163
J Clin Endocrinol Metab. 2020 Aug 1;105(8):
pubmed: 32382745
Int J Endocrinol Metab. 2017 Mar 07;15(2):e42311
pubmed: 28848608
Psychoneuroendocrinology. 2019 Feb;100:223-228
pubmed: 30388596
J Clin Endocrinol Metab. 1982 Jun;54(6):1164-8
pubmed: 6804477
N Engl J Med. 1988 Dec 15;319(24):1563-7
pubmed: 3200264
N Engl J Med. 1992 Feb 27;326(9):600-4
pubmed: 1734250
Sex Med. 2020 Jun;8(2):237-242
pubmed: 32184081
Arch Dis Child. 2016 Jan;101(1):101-6
pubmed: 26141541
Sex Med. 2015 Sep 17;3(4):269-79
pubmed: 26797061
J Sex Med. 2016 Dec;13(12):1787-1804
pubmed: 27914560
J Urol. 2017 Apr;197(4):1121-1126
pubmed: 27789218
Psychoneuroendocrinology. 2018 May;91:105-114
pubmed: 29547741