The cardiac methylome: A hidden layer of RNA modifications to regulate gene expression.
Journal
Journal of molecular and cellular cardiology
ISSN: 1095-8584
Titre abrégé: J Mol Cell Cardiol
Pays: England
ID NLM: 0262322
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
30
06
2020
revised:
27
09
2020
accepted:
24
11
2020
pubmed:
7
12
2020
medline:
24
11
2021
entrez:
6
12
2020
Statut:
ppublish
Résumé
Post-transcriptional RNA modification has been observed in all kingdoms of life and more than a hundred different types of RNA modifications decorate the chemical and topological properties of these ribose nucleotides. These RNA modifications can potentially alter the RNA structure and also affect the binding affinity of proteins, thus regulating the mRNA stability as well as translation. Emerging evidence suggest that these modifications are not static, but are dynamic; vary upon different cues and are cell-type or tissue-specific. The cardiac transcriptome is not exceptional to such RNA modifications and is enriched with the abundant base methylation such as N
Identifiants
pubmed: 33279505
pii: S0022-2828(20)30334-5
doi: 10.1016/j.yjmcc.2020.11.011
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
40-51Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.