Correlates of protection against SARS-CoV-2 in rhesus macaques.

Adoptive Transfer Animals CD8-Positive T-Lymphocytes / cytology COVID-19 / immunology Disease Models, Animal Female Immunization, Passive Immunoglobulin G / administration & dosage Macaca mulatta / immunology Male Regression Analysis SARS-CoV-2 / immunology Viral Load / immunology COVID-19 Serotherapy

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
02 2021
Historique:
received: 05 09 2020
accepted: 25 11 2020
pubmed: 5 12 2020
medline: 3 3 2021
entrez: 4 12 2020
Statut: ppublish

Résumé

Recent studies have reported the protective efficacy of both natural

Identifiants

DOI: 10.1038/s41586-020-03041-6 PMID: 33276369 PMC: PMC7906955
pubmed: 33276369
doi: 10.1038/s41586-020-03041-6
pii: 10.1038/s41586-020-03041-6
pmc: PMC7906955
mid: NIHMS1649751
doi:

Substances chimiques

Immunoglobulin G 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

630-634

Subventions

Organisme : NIH HHS
ID : OD024917
Pays : United States
Organisme : NIH HHS
ID : AI129797
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI126603
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA260476
Pays : United States
Organisme : NIH HHS
ID : R01 OD024917
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI124377
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI128751
Pays : United States
Organisme : NIH HHS
ID : U42 OD021458
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI129797
Pays : United States
Organisme : NIH HHS
ID : P40 OD012217
Pays : United States

Références

Chandrashekar, A. et al. SARS-CoV-2 infection protects against rechallenge in rhesus macaques. Science 369, 812–817 (2020).
doi: 10.1126/science.abc4776
Wang, H. et al. Development of an inactivated vaccine candidate, BBIBP-CorV, with potent protection against SARS-CoV-2. Cell 182, 713–721 (2020).
doi: 10.1016/j.cell.2020.06.008
Gao, Q. et al. Development of an inactivated vaccine candidate for SARS-CoV-2. Science 369, 77–81 (2020).
doi: 10.1126/science.abc1932
Yu, J. et al. DNA vaccine protection against SARS-CoV-2 in rhesus macaques. Science 369, 806–811 (2020).
doi: 10.1126/science.abc6284
Mercado, N. B. et al. Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques. Nature 586, 583–588 (2020).
doi: 10.1038/s41586-020-2607-z
Corbett, K. S. et al. Evaluation of the mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates. N. Engl. J. Med. 383, 1544–1555 (2020).
doi: 10.1056/NEJMoa2024671
van Doremalen, N. et al. ChAdOx1 nCoV-19 vaccine prevents SARS-CoV-2 pneumonia in rhesus macaques. Nature 586, 578–582 (2020).
doi: 10.1038/s41586-020-2608-y
Yang, Z. Y. et al. A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice. Nature 428, 561–564 (2004).
doi: 10.1038/nature02463
Chung, A. W. et al. Dissecting polyclonal vaccine-induced humoral immunity against HIV using systems serology. Cell 163, 988–998 (2015).
doi: 10.1016/j.cell.2015.10.027
Brown, E. P. et al. Multiplexed Fc array for evaluation of antigen-specific antibody effector profiles. J. Immunol. Methods 443, 33–44 (2017).
doi: 10.1016/j.jim.2017.01.010
Wölfel, R. et al. Virological assessment of hospitalized patients with COVID-2019. Nature 581, 465–469 (2020).
doi: 10.1038/s41586-020-2196-x
Joyner, M. J. et al. Effect of convalescent plasma on mortality among hospitalized patients with COVID-19: initial three-month experience. Preprint at https://doi.org/10.1101/2020.08.12.20169359 (2020).
Casadevall, A., Joyner, M. J. & Pirofski, L. A. SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy. J. Clin. Invest. 130, 5112–5114 (2020).
doi: 10.1172/JCI139760
Schmitz, J. E. et al. Control of viremia in simian immunodeficiency virus infection by CD8
doi: 10.1126/science.283.5403.857
Zost, S. J. et al. Potently neutralizing and protective human antibodies against SARS-CoV-2. Nature 584, 443–449 (2020).
doi: 10.1038/s41586-020-2548-6
Shi, R. et al. A human neutralizing antibody targets the receptor-binding site of SARS-CoV-2. Nature 584, 120–124 (2020).
doi: 10.1038/s41586-020-2381-y
Robbiani, D. F. et al. Convergent antibody responses to SARS-CoV-2 in convalescent individuals. Nature 584, 437–442 (2020).
doi: 10.1038/s41586-020-2456-9

Auteurs

Katherine McMahan (K)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Jingyou Yu (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Noe B Mercado (NB)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-7769-7326

Carolin Loos (C)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0003-3680-0627

Lisa H Tostanoski (LH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-9255-5684

Abishek Chandrashekar (A)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-7821-5552

Jinyan Liu (J)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Lauren Peter (L)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-2105-7503

Caroline Atyeo (C)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Harvard Medical School, Boston, MA, USA.

Alex Zhu (A)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0003-1712-8310

Esther A Bondzie (EA)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Gabriel Dagotto (G)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0002-9872-6074

Makda S Gebre (MS)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.

Catherine Jacob-Dolan (C)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0001-6641-0342

Zhenfeng Li (Z)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Felix Nampanya (F)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Shivani Patel (S)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Laurent Pessaint (L)

Bioqual, Rockville, MD, USA.

Alex Van Ry (A)

Bioqual, Rockville, MD, USA.
ORCID: 0000-0002-1240-9044

Kelvin Blade (K)

Bioqual, Rockville, MD, USA.

Jake Yalley-Ogunro (J)

Bioqual, Rockville, MD, USA.

Mehtap Cabus (M)

Bioqual, Rockville, MD, USA.

Renita Brown (R)

Bioqual, Rockville, MD, USA.

Anthony Cook (A)

Bioqual, Rockville, MD, USA.

Elyse Teow (E)

Bioqual, Rockville, MD, USA.

Hanne Andersen (H)

Bioqual, Rockville, MD, USA.
ORCID: 0000-0003-1103-9608

Mark G Lewis (MG)

Bioqual, Rockville, MD, USA.

Douglas A Lauffenburger (DA)

Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0002-0050-989X

Galit Alter (G)

Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA.
ORCID: 0000-0002-7680-9215

Dan H Barouch (DH)

Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu.
Ragon Institute of MGH, MIT and Harvard, Cambridge, MA, USA. dbarouch@bidmc.harvard.edu.
Harvard Medical School, Boston, MA, USA. dbarouch@bidmc.harvard.edu.
Massachusetts Consortium on Pathogen Readiness, Boston, MA, USA. dbarouch@bidmc.harvard.edu.
ORCID: 0000-0001-5127-4659

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Classifications MeSH

Recherchemedicale.com › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Eucaryotes › Animaux › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca › Macaca mulatta › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Charge virale › Correlates of protection against SARS-CoV-2 in...
Recherchemedicale.com › Techniques d'investigation › Techniques immunologiques › Immunisation passive › Transfert adoptif › Sérothérapie COVID-19 › Correlates of protection against SARS-CoV-2 in...