Dynamics of diffusive cell signaling relays.
cell signaling
collective phenomena
diffusive waves
human
neutrophil swarming
physics of living systems
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
04 12 2020
04 12 2020
Historique:
received:
04
08
2020
accepted:
03
12
2020
pubmed:
5
12
2020
medline:
1
4
2021
entrez:
4
12
2020
Statut:
epublish
Résumé
In biological contexts as diverse as development, apoptosis, and synthetic microbial consortia, collections of cells or subcellular components have been shown to overcome the slow signaling speed of simple diffusion by utilizing diffusive relays, in which the presence of one type of diffusible signaling molecule triggers participation in the emission of the same type of molecule. This collective effect gives rise to fast-traveling diffusive waves. Here, in the context of cell signaling, we show that system dimensionality - the shape of the extracellular medium and the distribution of cells within it - can dramatically affect the wave dynamics, but that these dynamics are insensitive to details of cellular activation. As an example, we show that neutrophil swarming experiments exhibit dynamical signatures consistent with the proposed signaling motif. We further show that cell signaling relays generate much steeper concentration profiles than does simple diffusion, which may facilitate neutrophil chemotaxis.
Identifiants
pubmed: 33275097
doi: 10.7554/eLife.61771
pii: 61771
pmc: PMC7781602
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM092804
Pays : United States
Organisme : National Science Foundation
ID : 1752024
Pays : International
Organisme : National Science Foundation
ID : MRSEC DMR 14-20570
Pays : International
Informations de copyright
© 2020, Dieterle et al.
Déclaration de conflit d'intérêts
PD, JM, DI, AA No competing interests declared
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