Antiplasmodial and antileishmanial flavonoids from Mundulea sericea.
Antimalarials
/ isolation & purification
Antineoplastic Agents, Phytogenic
/ isolation & purification
Antiprotozoal Agents
/ isolation & purification
Cell Line, Tumor
Fabaceae
/ chemistry
Flavonoids
Humans
Kenya
Molecular Structure
Nitric Oxide
/ metabolism
Phytochemicals
/ isolation & purification
Plant Leaves
/ chemistry
Plant Roots
/ chemistry
Plasmodium falciparum
/ drug effects
Antileishmanial
Antiplasmodial
Cytotoxicity
Flavanonol
Flavonol
Leguminosae
Mundulea sericea
Journal
Fitoterapia
ISSN: 1873-6971
Titre abrégé: Fitoterapia
Pays: Netherlands
ID NLM: 16930290R
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
04
07
2020
revised:
18
10
2020
accepted:
24
11
2020
pubmed:
4
12
2020
medline:
14
4
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
Five known compounds (1-5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6-8). The structures were elucidated using NMR spectroscopic and mass spectrometric analyses. The absolute configuration of 1 was established using ECD spectroscopy. In an antiplasmodial activity assay, compound 1 showed good activity with an IC
Identifiants
pubmed: 33271256
pii: S0367-326X(20)30378-6
doi: 10.1016/j.fitote.2020.104796
pii:
doi:
Substances chimiques
Antimalarials
0
Antineoplastic Agents, Phytogenic
0
Antiprotozoal Agents
0
Flavonoids
0
Phytochemicals
0
lupinifolin
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104796Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.