Cervical cytomegalovirus reactivation, cytokines and spontaneous preterm birth in Kenyan women.
Adult
Case-Control Studies
Cervix Uteri
/ metabolism
Cytokines
/ metabolism
Cytomegalovirus
/ physiology
Female
Gestational Age
Humans
Infant, Newborn
Kenya
Logistic Models
Pregnancy
Pregnancy Trimester, Third
Premature Birth
/ physiopathology
Prospective Studies
Virus Activation
/ physiology
Virus Shedding
/ physiology
Young Adult
cytokines
cytomegalovirus
preterm birth
sub-Saharan Africa
Journal
Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
26
06
2020
revised:
12
11
2020
accepted:
20
11
2020
pubmed:
4
12
2020
medline:
28
9
2021
entrez:
3
12
2020
Statut:
ppublish
Résumé
Genital cytomegalovirus (CMV) reactivation is common during the third trimester of pregnancy. We hypothesized that cervical CMV shedding may increase risk of spontaneous preterm birth (sPTB) through the release of inflammatory cytokines in the cervix. We conducted a nested case-control analysis to determine the relationship between CMV shedding and sPTB using data and samples from a prospective cohort study in western Kenya. Women who delivered between 28 + 0 and 33 + 6 weeks gestation were matched by gestational age at sample collection to controls who delivered ≥ 37 + 0 weeks. Levels of CMV DNA and interleukin (IL)-1 beta (β), IL-6, IL-8 and tumor necrosis factor (TNF)-α were measured in cervical swabs. We used conditional logistic regression to assess relationships between CMV shedding, cervical cytokine levels and sPTB. Among 86 cases and 86 matched controls, cervical CMV levels were not significantly associated with sPTB [odds ratio (OR) = 1·23, 95% confidence interval (CI) = 0·59-2·56], but were significantly associated with higher levels of cervical IL-6 (β = 0·15, 95% CI = 0·02-0·29) and TNF-α (β = 0·14, 95% CI = 0·01-0·27). In univariate analysis, higher odds of sPTB was associated with higher cervical IL-6 levels (OR = 1·54, 95% CI = 1·00-2·38), but not with other cervical cytokines. In this cohort of Kenyan women, we did not find a significant association between cervical CMV shedding and sPTB before 34 weeks.
Identifiants
pubmed: 33270222
doi: 10.1111/cei.13558
pmc: PMC7874830
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
472-479Subventions
Organisme : NIAID NIH HHS
ID : K01 AI116298
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI027757
Pays : United States
Organisme : NIH HHS
ID : P01 HSD 064915
Pays : United States
Informations de copyright
© 2020 British Society for Immunology.
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