Reduced fatty acid uptake aggravates cardiac contractile dysfunction in streptozotocin-induced diabetic cardiomyopathy.
Acetylation
Animals
Ceramides
/ metabolism
Citric Acid Cycle
Diabetic Cardiomyopathies
/ metabolism
Energy Metabolism
Fatty Acids
/ metabolism
Female
Glucose
/ metabolism
Glycolysis
Ketone Bodies
/ metabolism
Male
Mice, Inbred C57BL
Mice, Knockout
Myocardial Contraction
Streptozocin
Ventricular Dysfunction, Left
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
30 11 2020
30 11 2020
Historique:
received:
09
06
2020
accepted:
18
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
18
3
2021
Statut:
epublish
Résumé
Diabetes is an independent risk factor for the development of heart failure. Increased fatty acid (FA) uptake and deranged utilization leads to reduced cardiac efficiency and accumulation of cardiotoxic lipids, which is suggested to facilitate diabetic cardiomyopathy. We studied whether reduced FA uptake in the heart is protective against streptozotocin (STZ)-induced diabetic cardiomyopathy by using mice doubly deficient in fatty acid binding protein 4 (FABP4) and FABP5 (DKO mice). Cardiac contractile dysfunction was aggravated 8 weeks after STZ treatment in DKO mice. Although compensatory glucose uptake was not reduced in DKO-STZ hearts, total energy supply, estimated by the pool size in the TCA cycle, was significantly reduced. Tracer analysis with
Identifiants
pubmed: 33257783
doi: 10.1038/s41598-020-77895-1
pii: 10.1038/s41598-020-77895-1
pmc: PMC7705707
doi:
Substances chimiques
Ceramides
0
Fatty Acids
0
Ketone Bodies
0
Streptozocin
5W494URQ81
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20809Références
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