Long-Term Exposure to Temozolomide Affects Locomotor Activity and Cartilage Structure of Elderly Experimental Rats.
cartilage morphology
dexamethasone
glycosaminoglycan content
locomotor activity
temozolomide
Journal
Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304
Informations de publication
Date de publication:
26 Nov 2020
26 Nov 2020
Historique:
received:
09
10
2020
revised:
16
11
2020
accepted:
24
11
2020
entrez:
1
12
2020
pubmed:
2
12
2020
medline:
2
12
2020
Statut:
epublish
Résumé
Chemotherapy with temozolomide (TMZ) is an essential part of anticancer therapy of various malignant tumours; however, its long-term effects on patients' health and life quality need to be further investigated. Here, we studied the effects of TMZ and/or companion drug dexamethasone (DXM) on the locomotor activity and cartilage structure of elderly Wistar rats (
Identifiants
pubmed: 33255948
pii: biomedicines8120541
doi: 10.3390/biomedicines8120541
pmc: PMC7760849
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Russian Science Foundation
ID : 19-75-00051
Organisme : Scholarship of Russian Federation President for young scientists
ID : SP-1816.2019.4
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