BK
Animals
Calcium Channel Agonists
/ metabolism
Disease Models, Animal
Large-Conductance Calcium-Activated Potassium Channels
/ agonists
Pulmonary Arterial Hypertension
/ drug therapy
Quinolines
/ pharmacology
Rats
Rats, Wistar
Treatment Outcome
Vascular Remodeling
/ drug effects
Vascular Resistance
/ drug effects
Vasoconstriction
/ drug effects
Vasodilation
/ drug effects
Ventricular Function, Right
/ drug effects
BKCa channel opener
Monocrotaline
Pulmonary arterial hypertension
Right ventricular dysfunction
Journal
Cardiovascular drugs and therapy
ISSN: 1573-7241
Titre abrégé: Cardiovasc Drugs Ther
Pays: United States
ID NLM: 8712220
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
accepted:
16
11
2020
pubmed:
28
11
2020
medline:
18
12
2021
entrez:
27
11
2020
Statut:
ppublish
Résumé
In the present study, the therapeutic efficacy of a selective BK PAH was induced in male Wistar rats by a single injection of MCT. After two weeks, the MCT-treated group was divided into two groups that were either treated with compound X or vehicle. Compound X was administered daily at 28 mg/kg. Electrocardiographic, echocardiographic, and haemodynamic analyses were performed; ex vivo evaluations of pulmonary artery reactivity, right ventricle (RV) and lung histology as well as expression levels of α and β myosin heavy chain, brain natriuretic peptide, and cytokines (TNFα and IL10) in heart tissue were performed. Pulmonary artery rings of the PAH group showed a lower vasodilatation response to acetylcholine, suggesting endothelial dysfunction. Compound X promoted strong vasodilation in pulmonary artery rings of both control and MCT-induced PAH rats. The untreated hypertensive rats presented remodelling of pulmonary arterioles associated with increased resistance to pulmonary flow; increased systolic pressure, hypertrophy and fibrosis of the RV; prolongation of the QT and T The use of a selective and potent opener to activate the BK
Identifiants
pubmed: 33245463
doi: 10.1007/s10557-020-07115-5
pii: 10.1007/s10557-020-07115-5
doi:
Substances chimiques
Calcium Channel Agonists
0
Large-Conductance Calcium-Activated Potassium Channels
0
Quinolines
0
1,2,3,4-tetrahydroquinoline
CCR50N1Z9G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
719-732Références
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