Cellular therapies in organ transplantation.
cell therapy
immunomodulation
mesenchymal stromal cells
regeneration
regulatory T-cells
regulatory macrophages
Journal
Transplant international : official journal of the European Society for Organ Transplantation
ISSN: 1432-2277
Titre abrégé: Transpl Int
Pays: Switzerland
ID NLM: 8908516
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
28
09
2020
revised:
15
10
2020
accepted:
13
11
2020
pubmed:
19
11
2020
medline:
29
6
2021
entrez:
18
11
2020
Statut:
ppublish
Résumé
Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury-related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies.
Identifiants
pubmed: 33207013
doi: 10.1111/tri.13789
pmc: PMC7898347
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
233-244Subventions
Organisme : Wellcome Trust
ID : 211122/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_18059
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N027930/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. Transplant International published by John Wiley & Sons Ltd on behalf of Steunstichting ESOT.
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