Cell refractive index: Models, insights, applications and future perspectives.
Cell biology
Cell refractive index
Interferometry
Light propagation
Optical imaging
Refractive index
Scattering
Journal
Photodiagnosis and photodynamic therapy
ISSN: 1873-1597
Titre abrégé: Photodiagnosis Photodyn Ther
Pays: Netherlands
ID NLM: 101226123
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
28
09
2020
revised:
26
10
2020
accepted:
02
11
2020
pubmed:
15
11
2020
medline:
15
5
2021
entrez:
14
11
2020
Statut:
ppublish
Résumé
Cell refractive index (RI) is an intrinsic optical parameter that governs the propagation of light (i.e., scattering and absorption) in the cell matrix. The RI of cell is sensitively correlated with its mass distribution and thereby has the capability to provide important insights for diverse biological models. Herein, we review the cell refractive index and the fundamental models for measurement of cell RI, summarize the published RI data of cell and cell organelles and discuss the associated insights. Illustrative applications of cell RI in cell biology are also outlined. Finally, future research trends and applications of cell RI, including novel imaging techniques, reshaping flow cytometry and microfluidic platforms for single cell manipulation are discussed. The rapid technological advances in optical imaging integrated with microfluidic regime seems to enable deeper understanding of subcellular dynamics with high spatio-temporal resolution in real time.
Identifiants
pubmed: 33188939
pii: S1572-1000(20)30450-6
doi: 10.1016/j.pdpdt.2020.102096
pii:
doi:
Substances chimiques
Photosensitizing Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102096Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.