Current prognostic and predictive biomarkers for gastrointestinal tumors in clinical practice.
immunohistochemistry
molecular pathology
predictive markers
prognostic markers
targeted therapy
Journal
Pathologica
ISSN: 1591-951X
Titre abrégé: Pathologica
Pays: Italy
ID NLM: 0401123
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
24
06
2020
accepted:
24
06
2020
entrez:
12
11
2020
pubmed:
13
11
2020
medline:
25
8
2021
Statut:
ppublish
Résumé
The pathologist emerged in the personalized medicine era as a central actor in the definition of the most adequate diagnostic and therapeutic algorithms. In the last decade, gastrointestinal oncology has seen a significantly increased clinical request for the integration of novel prognostic and predictive biomarkers in histopathological reports. This request couples with the significant contraction of invasive sampling of the disease, thus conferring to the pathologist the role of governor for both proper pathologic characterization and customized processing of the biospecimens. This overview will focus on the most commonly adopted immunohistochemical and molecular biomarkers in the routine clinical characterization of gastrointestinal neoplasms referring to the most recent published recommendations, guidelines and expert opinions.
Identifiants
pubmed: 33179625
doi: 10.32074/1591-951X-158
pmc: PMC7931577
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
248-259Informations de copyright
Copyright © 2020 Società Italiana di Anatomia Patologica e Citopatologia Diagnostica, Divisione Italiana della International Academy of Pathology.
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