A motogenic GABAergic system of mononuclear phagocytes facilitates dissemination of coccidian parasites.
GABA
Neospora
Toxoplasma
apicomplexan
cell migration
human
immunology
infectious disease
inflammation
microbiology
mouse
myeloid cells
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
12 11 2020
12 11 2020
Historique:
received:
29
06
2020
accepted:
11
11
2020
pubmed:
13
11
2020
medline:
23
3
2021
entrez:
12
11
2020
Statut:
epublish
Résumé
Gamma-aminobutyric acid (GABA) serves diverse biological functions in prokaryotes and eukaryotes, including neurotransmission in vertebrates. Yet, the role of GABA in the immune system has remained elusive. Here, a comprehensive characterization of human and murine myeloid mononuclear phagocytes revealed the presence of a conserved and tightly regulated GABAergic machinery with expression of GABA metabolic enzymes and transporters, GABA-A receptors and regulators, and voltage-dependent calcium channels. Infection challenge with the common coccidian parasites
Identifiants
pubmed: 33179597
doi: 10.7554/eLife.60528
pii: 60528
pmc: PMC7685707
doi:
pii:
Substances chimiques
gamma-Aminobutyric Acid
56-12-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Vetenskapsrådet
ID : 2018-02411
Pays : International
Organisme : Olle Engkvist Foundation
ID : 193-609
Pays : International
Organisme : Stiftelsen Olle Engkvist Byggmästare
ID : 193-609
Pays : International
Informations de copyright
© 2020, Bhandage et al.
Déclaration de conflit d'intérêts
AB, GO, SK, ET, KL, MV, AB No competing interests declared
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