Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail.

Adult Alkaloids / pharmacokinetics Biological Products / chemistry Cross-Over Studies Drug Evaluation / methods Female Furosemide / pharmacokinetics HEK293 Cells Herb-Drug Interactions Humans Hydrastis / chemistry Male Metformin / pharmacokinetics Midazolam / pharmacokinetics Organic Anion Transporters / antagonists & inhibitors Organic Cation Transport Proteins / antagonists & inhibitors Plant Extracts / chemistry Rosuvastatin Calcium / pharmacokinetics

Journal

Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741

Informations de publication

Date de publication:
05 2021
Historique:
received: 01 09 2020
accepted: 27 10 2020
pubmed: 12 11 2020
medline: 16 9 2021
entrez: 11 11 2020
Statut: ppublish

Résumé

The botanical natural product goldenseal can precipitate clinical drug interactions by inhibiting cytochrome P450 (CYP) 3A and CYP2D6. Besides P-glycoprotein, effects of goldenseal on other clinically relevant transporters remain unknown. Established transporter-expressing cell systems were used to determine the inhibitory effects of a goldenseal extract, standardized to the major alkaloid berberine, on transporter activity. Using recommended basic models, the extract was predicted to inhibit the efflux transporter BCRP and uptake transporters OATP1B1/3. Using a cocktail approach, effects of the goldenseal product on BCRP, OATP1B1/3, OATs, OCTs, MATEs, and CYP3A were next evaluated in 16 healthy volunteers. As expected, goldenseal increased the area under the plasma concentration-time curve (AUC

Identifiants

DOI: 10.1002/cpt.2107 PMID: 33174626 PMC: PMC8058163
pubmed: 33174626
doi: 10.1002/cpt.2107
pmc: PMC8058163
mid: NIHMS1647412
doi:

Substances chimiques

Alkaloids 0
Biological Products 0
Organic Anion Transporters 0
Organic Cation Transport Proteins 0
Plant Extracts 0
Furosemide 7LXU5N7ZO5
Rosuvastatin Calcium 83MVU38M7Q
Metformin 9100L32L2N
Midazolam R60L0SM5BC

Types de publication

Clinical Trial Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1342-1352

Subventions

Organisme : NCCIH NIH HHS
ID : U54 AT008909
Pays : United States

Informations de copyright

© 2020 The Authors. Clinical Pharmacology & Therapeutics © 2020 American Society for Clinical Pharmacology and Therapeutics.

Références

Mol Pharm. 2019 Jun 3;16(6):2342-2353
pubmed: 31039308
CPT Pharmacometrics Syst Pharmacol. 2018 Nov;7(11):739-747
pubmed: 30175555
Clin Pharmacol Ther. 2005 May;77(5):415-26
pubmed: 15900287
Mol Pharmacol. 2001 May;59(5):1277-86
pubmed: 11306713
J Am Soc Nephrol. 2002 Apr;13(4):866-74
pubmed: 11912245
J Pharm Sci. 2002 Dec;91(12):2614-21
pubmed: 12434406
J Steroid Biochem Mol Biol. 2019 Jul;191:105350
pubmed: 30959153
Anal Chim Acta. 2020 Jan 25;1095:38-47
pubmed: 31864629
Clin Transl Sci. 2020 Jul;13(4):693-699
pubmed: 31981398
J Pharm Sci. 2017 Sep;106(9):2245-2250
pubmed: 28495567
Afr J Tradit Complement Altern Med. 2011;8(5 Suppl):152-63
pubmed: 22754069
Drug Metab Dispos. 2007 Feb;35(2):240-5
pubmed: 17079360
J Pharmacol Exp Ther. 2015 Mar;352(3):519-28
pubmed: 25563903
J Pharm Biomed Anal. 2007 Aug 15;44(4):931-7
pubmed: 17531424
Mol Pharm. 2015 Dec 7;12(12):4301-10
pubmed: 26528626
Food Chem Toxicol. 2018 Oct;120:439-447
pubmed: 30031041
J Basic Clin Pharm. 2014 Jun;5(3):79-83
pubmed: 25278671
J Clin Pharmacol. 1999 Jul;39(7):664-9
pubmed: 10392320
Drug Metab Dispos. 2018 May;46(5):552-560
pubmed: 29467215
Clin Pharmacol Ther. 2021 Jan;109(1):55-64
pubmed: 32460379
Drug Metab Dispos. 2020 Oct;48(10):1104-1112
pubmed: 32601103
J Nat Prod. 2014 Apr 25;77(4):766-72
pubmed: 24593257
Eur J Clin Pharmacol. 2012 Feb;68(2):213-7
pubmed: 21870106
Mol Nutr Food Res. 2008 Jul;52(7):755-63
pubmed: 18214849
Gastroenterology. 2006 May;130(6):1793-806
pubmed: 16697742
Curr Drug Metab. 2007 Oct;8(7):676-84
pubmed: 17979655
Anal Bioanal Chem. 2020 Jul;412(18):4273-4286
pubmed: 32347364
Diabetes Care. 2019 Jun;42(6):1027-1033
pubmed: 30885951
Drug Metab Dispos. 2020 Oct;48(10):1018-1027
pubmed: 32591416
Curr Protoc Toxicol. 2012 Nov;Chapter 23:Unit 23.4
pubmed: 23169269
Eur J Clin Pharmacol. 2005 Sep;61(8):567-72
pubmed: 16133554
Planta Med. 2007 Jul;73(8):731-41
pubmed: 17611934
Metabolism. 2008 May;57(5):712-7
pubmed: 18442638
Nat Prod Rep. 2019 Aug 14;36(8):1196-1221
pubmed: 30681109
Phytomedicine. 2000 Jul;7(4):273-82
pubmed: 10969720
J Pharmacol Exp Ther. 2004 Jan;308(1):2-9
pubmed: 14576340
Mol Pharmacol. 2013 Aug;84(2):182-9
pubmed: 23680637
Biol Pharm Bull. 2019;42(7):1226-1229
pubmed: 31257298
Clin Pharmacol Ther. 2008 Jan;83(1):61-9
pubmed: 17495878
J Nat Prod. 2001 Oct;64(10):1286-93
pubmed: 11678652
Drug Des Devel Ther. 2018 Dec 20;13:129-139
pubmed: 30587933
Kidney Int. 2000 Apr;57(4):1608-16
pubmed: 10760096
J Pharmacol Exp Ther. 2019 Jan;368(1):125-135
pubmed: 30314992

Auteurs

James T Nguyen (JT)

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.

Dan-Dan Tian (DD)

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.

Rakshit S Tanna (RS)

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.

Deena L Hadi (DL)

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.

Sumit Bansal (S)

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.

Justina C Calamia (JC)

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.

Christopher M Arian (CM)

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.

Laura M Shireman (LM)

Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.

Bálint Molnár (B)

SOLVO Biotechnology, SZTE Biológiai Epület, University of Szeged, Szeged, Hungary.

Miklós Horváth (M)

SOLVO Biotechnology, SZTE Biológiai Epület, University of Szeged, Szeged, Hungary.

Joshua J Kellogg (JJ)

Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.

Matthew E Layton (ME)

Elson S. Floyd College of Medicine, Washington State University, Spokane, Washington, USA.

John R White (JR)

Department of Pharmacotherapy, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.

Nadja B Cech (NB)

Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.
Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina, USA.

Richard D Boyce (RD)

Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.
Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Jashvant D Unadkat (JD)

Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.

Kenneth E Thummel (KE)

Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.
Department of Pharmaceutics, School of Pharmacy, University of Washington, Seattle, Washington, USA.

Mary F Paine (MF)

Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA.
Center of Excellence for Natural Product Drug Interaction Research, Spokane, Washington, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Composés hétérocycliques › Alcaloïdes › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Mélanges complexes › Produits biologiques › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Études croisées › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Techniques d'investigation › Évaluation de médicament › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › Sulfamides › Furosémide › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Cellules › Cellules épithéliales › Cellules HEK293 › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Interactions médicaments-plantes › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Ranunculales › Ranonculaceae › Hydrastis › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Composés chimiques organiques › Amidines › Guanidines › Biguanides › Metformine › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzazépines › Benzodiazépines › Midazolam › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs d'anions › Transporteurs d'anions organiques › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Protéines transporteurs de solutés › Transporteurs de cations organiques › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Préparations pharmaceutiques › Extraits de plantes › Assessing Transporter-Mediated Natural...
Recherchemedicale.com › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Rosuvastatine de calcium › Assessing Transporter-Mediated Natural...