Neural tube defects: role of lithium carbonate exposure in embryonic neural development in a murine model.

5'-Nucleotidase / metabolism Animals Central Nervous System / drug effects Disease Models, Animal Female Glycogen Synthase Kinase 3 beta / metabolism Inositol / metabolism Lithium Carbonate / adverse effects Maternal Exposure Mice Mice, Inbred C57BL Neural Tube Defects / chemically induced Pregnancy

Journal

Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714

Informations de publication

Date de publication:
07 2021
Historique:
received: 26 08 2019
accepted: 18 10 2020
revised: 30 09 2020
pubmed: 12 11 2020
medline: 9 2 2022
entrez: 11 11 2020
Statut: ppublish

Résumé

Lithium carbonate (Li C57BL/6 mice were injected with different doses of Li The NTDs incidence was 33.7% following Li Lithium-induced NTDs model in C57BL/6 mice was established. Enhanced cell proliferation and decreased apoptosis following lithium exposure were closely associated with the impairment of inositol biosynthesis, which may contribute to lithium-induced NTDs. Impairment of inositol biosynthesis has an important role in lithium exposure-induced NTDs in mice model. Lithium-induced NTDs model on C57BL/6 mice was established. Based on this NTDs model, lithium-induced impairment of inositol biosynthesis resulted in the imbalance between cell proliferation and apoptosis, which may contribute to lithium-induced NTDs. Providing evidence to further understand the molecular mechanisms of lithium-induced NTDs and enhancing its primary prevention.

Sections du résumé

BACKGROUND
Lithium carbonate (Li
METHODS
C57BL/6 mice were injected with different doses of Li
RESULTS
The NTDs incidence was 33.7% following Li
CONCLUSIONS
Lithium-induced NTDs model in C57BL/6 mice was established. Enhanced cell proliferation and decreased apoptosis following lithium exposure were closely associated with the impairment of inositol biosynthesis, which may contribute to lithium-induced NTDs.
IMPACT
Impairment of inositol biosynthesis has an important role in lithium exposure-induced NTDs in mice model. Lithium-induced NTDs model on C57BL/6 mice was established. Based on this NTDs model, lithium-induced impairment of inositol biosynthesis resulted in the imbalance between cell proliferation and apoptosis, which may contribute to lithium-induced NTDs. Providing evidence to further understand the molecular mechanisms of lithium-induced NTDs and enhancing its primary prevention.

Identifiants

DOI: 10.1038/s41390-020-01244-1 PMID: 33173184
pubmed: 33173184
doi: 10.1038/s41390-020-01244-1
pii: 10.1038/s41390-020-01244-1
doi:

Substances chimiques

Lithium Carbonate 2BMD2GNA4V
Inositol 4L6452S749
Glycogen Synthase Kinase 3 beta EC 2.7.11.1
Gsk3b protein, mouse EC 2.7.11.1
5'-Nucleotidase EC 3.1.3.5

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

82-92

Informations de copyright

© 2020. International Pediatric Research Foundation, Inc.

Références

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Auteurs

Shen Li (S)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.
Graduate School of Peking Union Medical College, 100005, Beijing, China.

Danqing Luo (D)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.

Huixuan Yue (H)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.
Graduate School of Peking Union Medical College, 100005, Beijing, China.

Jianjun Lyu (J)

National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, 100176, Beijing, China.

Yanwei Yang (Y)

National Center for Safety Evaluation of Drugs, National Institutes for Food and Drug Control, 100176, Beijing, China.

Tingting Gao (T)

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, 100124, Beijing, China.

Yu Liu (Y)

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, 100124, Beijing, China.

Jiaxing Qin (J)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.

Xiuwei Wang (X)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.

Zhen Guan (Z)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.

Fang Wang (F)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.

Feng Zhang (F)

Food Safety Inspection and Quarantine Institution Research Institute of China, 100025, Beijing, China.

Bo Niu (B)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.

Ting Zhang (T)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China.

Rugang Zhong (R)

Beijing Key Laboratory of Environmental & Viral Oncology, College of Life Science & Bioengineering, Beijing University of Technology, 100124, Beijing, China.

Jin Guo (J)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China. guoguo0520@sina.com.

Jianhua Wang (J)

Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Institute of Pediatrics, 100020, Beijing, China. fywjh@163.com.
Graduate School of Peking Union Medical College, 100005, Beijing, China. fywjh@163.com.

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Classifications MeSH

Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Nucleotidases › 5'-Nucleotidase › Neural tube defects: role of lithium carbonate...
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