Impact of the Post-Transplant Period and Lifestyle Diseases on Human Gut Microbiota in Kidney Graft Recipients.
16S rRNA gene
amplicon sequencing
bioinformatics
dysbiosis
kidney transplantation
Journal
Microorganisms
ISSN: 2076-2607
Titre abrégé: Microorganisms
Pays: Switzerland
ID NLM: 101625893
Informations de publication
Date de publication:
04 Nov 2020
04 Nov 2020
Historique:
received:
08
09
2020
revised:
28
10
2020
accepted:
30
10
2020
entrez:
7
11
2020
pubmed:
8
11
2020
medline:
8
11
2020
Statut:
epublish
Résumé
Gaining long-term graft function and patient life quality remain critical challenges following kidney transplantation. Advances in immunology, gnotobiotics, and culture-independent molecular techniques have provided growing insights into the complex relationship of the microbiome and the host. However, little is known about the over time-shift of the gut microbiota in the context of kidney transplantation and its impact on both graft and health stability. Here we aimed to characterize the structure of gut microbiota within stable kidney graft recipients. We enrolled forty kidney transplant patients after at least three months of transplantation and compared them to eighteen healthy controls. The overall microbial community structure of the kidney transplanted group was clearly different from control subjects. We found lower relative abundances of Actinobacteria, Bacteroidetes, and Verrucomicrobia within the patient group and a higher abundance of Proteobacteria compared to the control group. Both richness and Shannon diversity indexes were significantly lower in the kidney graft recipients than in healthy controls. Post-graft period was positively correlated with the relative abundance of the Proteobacteria phylum, especially
Identifiants
pubmed: 33158078
pii: microorganisms8111724
doi: 10.3390/microorganisms8111724
pmc: PMC7694191
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Erasmus+
ID : KA107
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