Thiophenols as Protic Nucleophilic Triggers in Aryne Three-Component Coupling.
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
20 Nov 2020
20 Nov 2020
Historique:
pubmed:
6
11
2020
medline:
6
11
2020
entrez:
5
11
2020
Statut:
ppublish
Résumé
The synthetic potential of thiophenols as a protic nucleophilic trigger in the transition-metal-free and Grignard-reagent-free three-component coupling involving arynes is demonstrated. Employing aldehydes as the third component, the reaction allowed the mild and broad scope synthesis of 2-arylthio benzyl alcohol derivatives in good yields. Moreover, selenophenol could be used as the nucleophilic trigger, and activated ketones could be used as the third component in this reaction.
Identifiants
pubmed: 33151079
doi: 10.1021/acs.orglett.0c03494
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM