Heart Failure With Mid-range or Recovered Ejection Fraction: Differential Determinants of Transition.
AF
Heart failure phenotype
ischaemic aetiology
mid-range ejection fraction
predictors of transition
prognosis
Journal
Cardiac failure review
ISSN: 2057-7540
Titre abrégé: Card Fail Rev
Pays: England
ID NLM: 101696210
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
10
05
2020
accepted:
13
07
2020
entrez:
2
11
2020
pubmed:
3
11
2020
medline:
3
11
2020
Statut:
epublish
Résumé
The recent definition of an intermediate clinical phenotype of heart failure (HF) based on an ejection fraction (EF) of between 40% and 49%, namely HF with mid-range EF (HFmrEF), has fuelled investigations into the clinical profile and prognosis of this patient group. HFmrEF shares common clinical features with other HF phenotypes, such as a high prevalence of ischaemic aetiology, as in HF with reduced EF (HFrEF), or hypertension and diabetes, as in HF with preserved EF (HFpEF), and benefits from the cornerstone drugs indicated for HFrEF. Among the HF phenotypes, HFmrEF is characterised by the highest rate of transition to either recovery or worsening of the severe systolic dysfunction profile that is the target of disease-modifying therapies, with opposite prognostic implications. This article focuses on the epidemiology, clinical characteristics and therapeutic approaches for HFmrEF, and discusses the major determinants of transition to HFpEF or HFrEF.
Identifiants
pubmed: 33133642
doi: 10.15420/cfr.2020.13
pmc: PMC7592465
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
e28Informations de copyright
Copyright © 2020, Radcliffe Cardiology.
Déclaration de conflit d'intérêts
Disclosure: The authors have no conflicts of interest to declare.
Références
Eur J Heart Fail. 2014 Oct;16(10):1049-55
pubmed: 25210008
Eur J Heart Fail. 2018 Aug;20(8):1230-1239
pubmed: 29431256
Circ Heart Fail. 2017 Jun;10(6):
pubmed: 28559418
Eur J Heart Fail. 2017 Dec;19(12):1606-1614
pubmed: 28371075
N Engl J Med. 2019 Nov 21;381(21):1995-2008
pubmed: 31535829
Eur J Heart Fail. 2017 Apr;19(4):512-521
pubmed: 27813223
Indian Heart J. 2019 May - Jun;71(3):229-234
pubmed: 31543195
Eur J Heart Fail. 2017 Dec;19(12):1597-1605
pubmed: 29024350
Am J Cardiol. 2009 Mar 15;103(6):845-51
pubmed: 19268743
BMC Cardiovasc Disord. 2019 Sep 2;19(1):209
pubmed: 31477021
Eur J Heart Fail. 2017 Dec;19(12):1615-1623
pubmed: 28387002
Cardiovasc Ther. 2018 Aug;36(4):e12435
pubmed: 29771478
ESC Heart Fail. 2019 Oct;6(5):927-935
pubmed: 31400090
J Card Fail. 2004 Jun;10(3):250-7
pubmed: 15190536
N Engl J Med. 2016 Mar 17;374(11):1094
pubmed: 26981940
J Cardiovasc Med (Hagerstown). 2018 Jun;19(6):297-303
pubmed: 29570491
Circ Cardiovasc Imaging. 2013 Sep;6(5):790-9
pubmed: 23934992
Circ Heart Fail. 2014 May;7(3):434-9
pubmed: 24563449
Int J Cardiol. 2017 Aug 1;240:265-270
pubmed: 28318662
N Engl J Med. 2019 Jan 24;380(4):347-357
pubmed: 30415602
Lancet. 2019 Jan 5;393(10166):61-73
pubmed: 30429050
Eur Heart J. 2016 Jul 14;37(27):2129-2200
pubmed: 27206819
Circulation. 2020 Feb 4;141(5):362-366
pubmed: 32011927
J Am Coll Cardiol. 2013 Jan 8;61(1):77-84
pubmed: 23199515
Eur Heart J. 2016 Feb 1;37(5):455-62
pubmed: 26374849
N Engl J Med. 1987 Jun 4;316(23):1429-35
pubmed: 2883575
JACC Cardiovasc Imaging. 2019 Oct;12(10):1917-1926
pubmed: 30219408
Eur J Heart Fail. 2018 Jul;20(7):1139-1145
pubmed: 29493058
JACC Heart Fail. 2017 Nov;5(11):763-771
pubmed: 29032140
JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 1):260-274
pubmed: 29413646
ESC Heart Fail. 2020 Jun;7(3):964-972
pubmed: 32233080
N Engl J Med. 2013 Dec 5;369(23):2253-8
pubmed: 24304055
Curr Heart Fail Rep. 2013 Dec;10(4):321-30
pubmed: 24014141
J Am Coll Cardiol. 2018 Sep 25;72(13):1557-1558
pubmed: 30236318
Circulation. 2020 Feb 4;141(5):352-361
pubmed: 31736342
JRSM Cardiovasc Dis. 2017 Oct 09;6:2048004017734476
pubmed: 29051817
N Engl J Med. 2019 Oct 24;381(17):1609-1620
pubmed: 31475794
N Engl J Med. 2017 Aug 17;377(7):644-657
pubmed: 28605608
Am J Cardiol. 2001 Aug 15;88(4):382-7
pubmed: 11545758
J Am Coll Cardiol. 2017 Nov 14;70(20):2476-2486
pubmed: 29141781
Eur Heart J. 2018 Jan 1;39(1):26-35
pubmed: 29040525
Eur Heart J. 2015 May 7;36(18):1090-7
pubmed: 25636745
Lancet. 2003 Sep 6;362(9386):767-71
pubmed: 13678869
Ann Intern Med. 2002 Oct 15;137(8):631-9
pubmed: 12379062
Circulation. 2014 Dec 23;130(25):2278-86
pubmed: 25301831
J Cardiol Cases. 2019 May 01;20(2):52-56
pubmed: 31440312
JAMA Cardiol. 2019 Mar 1;4(3):287-294
pubmed: 30810702
JAMA Cardiol. 2020 Sep 1;5(9):1027-1035
pubmed: 32936274
Clin Cardiol. 2014 Apr;37(4):222-6
pubmed: 24452755
Circulation. 2013 Oct 15;128(16):e240-327
pubmed: 23741058
Arq Bras Cardiol. 2019 Jul 15;112(6):784-790
pubmed: 31314831
Eur J Heart Fail. 2017 Dec;19(12):1586-1596
pubmed: 28295985
ESC Heart Fail. 2020 Feb;7(1):158-166
pubmed: 31903729
Circ Heart Fail. 2016 Apr;9(4):e002826
pubmed: 27009553
J Cardiovasc Magn Reson. 2018 Jan 11;20(1):4
pubmed: 29321034
JACC Heart Fail. 2016 Jun;4(6):464-72
pubmed: 27256749
Int J Cardiol. 2020 Aug 15;313:76-82
pubmed: 32360702
Eur J Heart Fail. 2017 Dec;19(12):1574-1585
pubmed: 28386917
J Am Coll Cardiol. 2018 Jan 23;71(3):306-317
pubmed: 29348023
J Clin Med. 2019 Nov 05;8(11):
pubmed: 31694263
BMJ Open. 2017 Dec 21;7(12):e018719
pubmed: 29273666
Circulation. 2014 Jun 10;129(23):2380-7
pubmed: 24799515
Lancet. 2003 Sep 6;362(9386):777-81
pubmed: 13678871
Int J Cardiol. 2018 Nov 15;271:132-139
pubmed: 30482453
Cardiol Res Pract. 2011 Jan 05;2011:798658
pubmed: 21253480
J Am Coll Cardiol. 2010 Jan 26;55(4):333-41
pubmed: 20117439
Europace. 2009 Mar;11(3):343-9
pubmed: 19240109
J Saudi Heart Assoc. 2019 Apr;31(2):100-105
pubmed: 30766004
Eur Heart J. 2012 Jul;33(14):1787-847
pubmed: 22611136
ESC Heart Fail. 2019 Aug;6(4):784-792
pubmed: 31268631
ESC Heart Fail. 2018 Dec;5(6):1008-1016
pubmed: 30211480
J Am Coll Cardiol. 2011 Mar 29;57(13):1468-76
pubmed: 21435516
Eur Heart J. 2013 Sep;34(33):2636-48, 2648a-2648d
pubmed: 23824828
ESC Heart Fail. 2020 Feb;7(1):339-347
pubmed: 31951680