Manuka Honey Induces Apoptosis of Epithelial Cancer Cells through Aquaporin-3 and Calcium Signaling.
AQP3
Ca2+ signaling
ROS
honey
manuka
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
27 Oct 2020
27 Oct 2020
Historique:
received:
07
10
2020
revised:
24
10
2020
accepted:
25
10
2020
entrez:
30
10
2020
pubmed:
31
10
2020
medline:
31
10
2020
Statut:
epublish
Résumé
Honey is a natural product with a long use in traditional medicine and is well recognized to regulate different biological events. It is an important source of various biological or pharmacological molecules and, therefore, there is a strong interest to explore their properties. Evidence is growing that honey may have the potential to be an anticancer agent acting through several mechanisms. Here we observed for the first time in a cancer cell line a possible mechanism through which honey could induce an alteration in the intracellular reactive oxygen species and homeostatic balance of intracellular calcium concentration leading to cell death by apoptosis. This mechanism seems to be enhanced by manuka honey's ability to maintain high H
Identifiants
pubmed: 33120979
pii: life10110256
doi: 10.3390/life10110256
pmc: PMC7692226
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : University of Piemonte Orientale
ID : Ricerca Locale 2019
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