Vitamin D
Diabetic complications
Vitamin D
Vitamin D deficiency
Vitamin D metabolite ratio
Vitamin D metabolites
Journal
BMC endocrine disorders
ISSN: 1472-6823
Titre abrégé: BMC Endocr Disord
Pays: England
ID NLM: 101088676
Informations de publication
Date de publication:
27 Oct 2020
27 Oct 2020
Historique:
received:
31
07
2020
accepted:
20
10
2020
entrez:
28
10
2020
pubmed:
29
10
2020
medline:
18
8
2021
Statut:
epublish
Résumé
Vitamin D deficiency is diagnosed by total serum 25-hydroxyvitamin D (25(OH)D) concentration and is associated with poor health and increased mortality; however, some populations have low 25(OH) D concentrations without manifestations of vitamin D deficiency. The Vitamin D Metabolite Ratio (VMR) has been suggested as a superior indicator of vitamin D status. Therefore, VMR was determined in a population with type 2 diabetes at high risk for vitamin D deficiency and correlated with diabetic complications. Four hundred sisty patients with type 2 diabetes (T2D) were recruited, all were vitamin D In this cross sectional study, whilst not causal, VMR-2 was shown to be the superior predictor of diabetic and cardiovascular complications though not demonstrative of causality in this cross-sectional study population over VMR-1, VMR-3 and the individual vitamin D concentration measurements; VMR-2 associated with both microvascular and cardiovascular indices and therefore may have utility in predicting the development of diabetic complications.
Sections du résumé
BACKGROUND
BACKGROUND
Vitamin D deficiency is diagnosed by total serum 25-hydroxyvitamin D (25(OH)D) concentration and is associated with poor health and increased mortality; however, some populations have low 25(OH) D concentrations without manifestations of vitamin D deficiency. The Vitamin D Metabolite Ratio (VMR) has been suggested as a superior indicator of vitamin D status. Therefore, VMR was determined in a population with type 2 diabetes at high risk for vitamin D deficiency and correlated with diabetic complications.
RESEARCH DESIGN AND METHODS
METHODS
Four hundred sisty patients with type 2 diabetes (T2D) were recruited, all were vitamin D
CONCLUSIONS
CONCLUSIONS
In this cross sectional study, whilst not causal, VMR-2 was shown to be the superior predictor of diabetic and cardiovascular complications though not demonstrative of causality in this cross-sectional study population over VMR-1, VMR-3 and the individual vitamin D concentration measurements; VMR-2 associated with both microvascular and cardiovascular indices and therefore may have utility in predicting the development of diabetic complications.
Identifiants
pubmed: 33109163
doi: 10.1186/s12902-020-00641-1
pii: 10.1186/s12902-020-00641-1
pmc: PMC7590744
doi:
Substances chimiques
Biomarkers
0
Vitamins
0
Cholecalciferol
1C6V77QF41
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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