Blood lipid markers are associated with hippocampal viscoelastic properties and memory in humans.
Cognitive impairment/decline
MRI
brain imaging
hippocampus
lipids
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
pubmed:
27
10
2020
medline:
31
7
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
Age-related memory loss shares similar risk factors as cardiometabolic diseases including elevated serum triglycerides (TGs) and low-density lipoprotein cholesterol (LDL-C) and reduced high-density lipoprotein cholesterol (HDL-C). The mechanisms linking these aberrant blood lipids to memory loss are not completely understood but may be partially mediated by reduced integrity of the hippocampus (HC), the primary brain structure for encoding and recalling memories. In this study, we tested the hypothesis that blood lipid markers are independently associated with memory performance and HC viscoelasticity-a noninvasive measure of brain tissue microstructural integrity assessed by high-resolution magnetic resonance elastography (MRE). Twenty-six individuals across the adult lifespan were recruited (14 M/12 F; mean age: 42 ± 15 y; age range: 22-78 y) and serum lipid profiles were related to episodic memory and HC viscoelasticity. All subjects were generally healthy without clinically abnormal blood lipids or memory loss. Episodic memory was negatively associated with the TG/HDL-C ratio. HC viscoelasticity was negatively associated with serum TGs and the TG/HDL-C ratio, independent of age and in the absence of associations with HC volume. These data, although cross-sectional, suggest that subtle differences in blood lipid profiles in healthy adults may contribute to a reduction in memory function and HC tissue integrity.
Identifiants
pubmed: 33103936
doi: 10.1177/0271678X20968032
pmc: PMC8142125
doi:
Substances chimiques
Biomarkers
0
Lipids
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1417-1427Subventions
Organisme : NIA NIH HHS
ID : K01 AG054731
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103653
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM113125
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG058853
Pays : United States
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