Renal Dysfunction among HIV-Infected Patients on Antiretroviral Therapy in Dar es Salaam, Tanzania: A Cross-Sectional Study.
Journal
International journal of nephrology
ISSN: 2090-214X
Titre abrégé: Int J Nephrol
Pays: United States
ID NLM: 101546753
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
06
2020
revised:
23
09
2020
accepted:
25
09
2020
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
epublish
Résumé
HIV-associated renal dysfunction is common among infected patients; the growing burden of this condition may be partly accounted for by improved survival attributed to sustained viral suppression with antiretroviral therapies (ART). Some ART regimens are nephrotoxic and may potentially contribute to renal dysfunction observed in these patients. This study aimed at investigating the prevalence of renal dysfunction among people living with HIV (PLHIV) on ART attending the care and treatment clinic (CTC). A cross-sectional study was conducted between June and October 2019 among adults living with HIV on ART for 6 months or more attending CTC at Muhimbili National Hospital in Dar es Salaam, Tanzania. A total of 287 participants were screened for proteinuria and microalbuminuria using the Cybow 300 urine analyzer. Serum creatinine was tested for all participants, and it was used to estimate glomerular filtration rate (eGFR) using the CKD-EPI formula. Out of 287 participants (72.1% female, mean age ± SD: 46.7 ± 10.6 years), about one-third (32.8%) had eGFR less than 90 ml/min, whereas 7% had eGFR less than 60 ml/min. Microalbuminuria and proteinuria were detected in 38.6% and 25.1% of participants, respectively. In the multivariate analysis, predictive determinants for renal dysfunction were higher viral loads (OR 2.5 (1.1-5.8), High prevalence of renal dysfunction among PLHIV on ART was noted in this study. Viral loads above 1000 cp/ml and diabetes mellitus were noted to be associated with increased risk for renal dysfunction.
Sections du résumé
BACKGROUND
BACKGROUND
HIV-associated renal dysfunction is common among infected patients; the growing burden of this condition may be partly accounted for by improved survival attributed to sustained viral suppression with antiretroviral therapies (ART). Some ART regimens are nephrotoxic and may potentially contribute to renal dysfunction observed in these patients. This study aimed at investigating the prevalence of renal dysfunction among people living with HIV (PLHIV) on ART attending the care and treatment clinic (CTC).
METHODS
METHODS
A cross-sectional study was conducted between June and October 2019 among adults living with HIV on ART for 6 months or more attending CTC at Muhimbili National Hospital in Dar es Salaam, Tanzania. A total of 287 participants were screened for proteinuria and microalbuminuria using the Cybow 300 urine analyzer. Serum creatinine was tested for all participants, and it was used to estimate glomerular filtration rate (eGFR) using the CKD-EPI formula.
RESULTS
RESULTS
Out of 287 participants (72.1% female, mean age ± SD: 46.7 ± 10.6 years), about one-third (32.8%) had eGFR less than 90 ml/min, whereas 7% had eGFR less than 60 ml/min. Microalbuminuria and proteinuria were detected in 38.6% and 25.1% of participants, respectively. In the multivariate analysis, predictive determinants for renal dysfunction were higher viral loads (OR 2.5 (1.1-5.8),
CONCLUSION
CONCLUSIONS
High prevalence of renal dysfunction among PLHIV on ART was noted in this study. Viral loads above 1000 cp/ml and diabetes mellitus were noted to be associated with increased risk for renal dysfunction.
Identifiants
pubmed: 33101732
doi: 10.1155/2020/8378947
pmc: PMC7568141
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8378947Informations de copyright
Copyright © 2020 Oswin Mwemezi et al.
Déclaration de conflit d'intérêts
The authors declare that there are no conflicts of interest regarding the publication of this paper.
Références
Am J Kidney Dis. 2012 May;59(5):628-35
pubmed: 22206742
Nephrol Dial Transplant. 2008 Feb;23(2):741-6
pubmed: 18065807
Clin Infect Dis. 2014 Nov 1;59(9):e96-138
pubmed: 25234519
AIDS. 2011 Jul 17;25(11):1421-5
pubmed: 21572304
PLoS One. 2015 Aug 26;10(8):e0136529
pubmed: 26309226
Nephrol Dial Transplant. 2013 Jun;28(6):1543-54
pubmed: 23444185
Diabetes Care. 2000 Aug;23(8):1108-12
pubmed: 10937506
Syst Rev. 2017 Oct 13;6(1):200
pubmed: 29029647
HIV AIDS (Auckl). 2019 Apr 05;11:61-67
pubmed: 31118824
Nat Rev Nephrol. 2009 Oct;5(10):591-8
pubmed: 19776781
HIV AIDS (Auckl). 2014 Dec 17;7:1-10
pubmed: 25565897
J Bras Nefrol. 2015 Apr-Jun;37(2):177-84
pubmed: 26154637