Venom complexity of
Bothrops atrox
Envenomation
Individual variation
Snake venom
Journal
The journal of venomous animals and toxins including tropical diseases
ISSN: 1678-9199
Titre abrégé: J Venom Anim Toxins Incl Trop Dis
Pays: Brazil
ID NLM: 101201501
Informations de publication
Date de publication:
12 Oct 2020
12 Oct 2020
Historique:
entrez:
26
10
2020
pubmed:
27
10
2020
medline:
27
10
2020
Statut:
epublish
Résumé
Variability in snake venoms is a well-studied phenomenon. However, sex-based variation of Venoms were collected from five females and four males born from a snake captured from the wild in São Bento (Maranhão, Brazil), and kept in the Laboratory of Herpetology of Butantan Intitute. The venoms were analyzed individually and as a pool of each gender. The assays consisted in protein quantification, 1-DE, mass spectrometry, proteolytic, phospholipase A Electrophoretic profiles of male's and female's venom pools were quite similar, with minor sex-based variation. Male venom showed higher LAAO, PLA Although differences between female and male venoms were observed, our results show that individual variations are significant even between siblings, highlighting that biological activities of venoms and its composition are influenced by other factors beyond gender.
Sections du résumé
BACKGROUND
BACKGROUND
Variability in snake venoms is a well-studied phenomenon. However, sex-based variation of
METHODS
METHODS
Venoms were collected from five females and four males born from a snake captured from the wild in São Bento (Maranhão, Brazil), and kept in the Laboratory of Herpetology of Butantan Intitute. The venoms were analyzed individually and as a pool of each gender. The assays consisted in protein quantification, 1-DE, mass spectrometry, proteolytic, phospholipase A
RESULTS
RESULTS
Electrophoretic profiles of male's and female's venom pools were quite similar, with minor sex-based variation. Male venom showed higher LAAO, PLA
CONCLUSION
CONCLUSIONS
Although differences between female and male venoms were observed, our results show that individual variations are significant even between siblings, highlighting that biological activities of venoms and its composition are influenced by other factors beyond gender.
Identifiants
pubmed: 33101399
doi: 10.1590/1678-9199-JVATITD-2020-0018
pmc: PMC7553035
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e20200018Déclaration de conflit d'intérêts
Competing interests: The authors declare that they have no competing interests.
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