The Role of Patients in Alopecia Areata Endpoint Development: Understanding Physical Signs and Symptoms.
Adolescent
Adult
Aged
Alopecia Areata
/ complications
Endpoint Determination
Extremities
Eye Diseases
/ etiology
Eyebrows
Eyelashes
Face
Female
Humans
Interviews as Topic
Male
Middle Aged
Nail Diseases
/ etiology
Nose
Outcome Assessment, Health Care
Patient Participation
Scalp
Severity of Illness Index
Symptom Assessment
Torso
Young Adult
Journal
The journal of investigative dermatology. Symposium proceedings
ISSN: 1529-1774
Titre abrégé: J Investig Dermatol Symp Proc
Pays: United States
ID NLM: 9609059
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
entrez:
25
10
2020
pubmed:
26
10
2020
medline:
24
9
2021
Statut:
ppublish
Résumé
Meaningful patient input to understand disease experience and patient expectations for improvement with treatment is essential for the selection and development of outcome measures for alopecia areata (AA) clinical trials. This study explored the physical signs and symptoms of AA through 30 semistructured interviews with adult (n = 25) and adolescent (n = 5) patients experienced with severe or very severe AA. Scalp hair loss was overwhelmingly the most important sign and symptom of AA. Nearly all patients (90%) considered scalp hair loss in their top three most bothersome physical signs and symptoms of AA, with 77% (n = 23) naming scalp hair loss as the most bothersome symptom. Other identified signs and symptoms in the top three most bothersome included eyebrow, eyelash, nose, body, and facial hair loss, as well as eye irritation and nail damage and/or appearance. Eyebrow (16%, n = 4), eyelash (4%, n = 1), nasal (4%, n = 1), and body (4%, n = 1) hair loss were identified by seven adult patients as the most bothersome signs and symptoms of AA. Conceptual saturation confirmed that a comprehensive understanding of this patient population's physical AA-related signs and symptoms was obtained. These findings indicate that the primary objective for new AA treatments for this patient population should be meaningful improvement in scalp hair growth to address the most troubling unmet need.
Identifiants
pubmed: 33099392
pii: S1087-0024(20)30016-2
doi: 10.1016/j.jisp.2020.05.006
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
S71-S77Subventions
Organisme : NIAMS NIH HHS
ID : R13 AR074890
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.