Air pollution during infancy and lung function development into adolescence: The GINIplus/LISA birth cohorts study.
Children
Environmental exposure
Respiratory health
Journal
Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
07
07
2020
revised:
05
10
2020
accepted:
06
10
2020
pubmed:
26
10
2020
medline:
22
4
2021
entrez:
25
10
2020
Statut:
ppublish
Résumé
Limited evidence exists on how air pollution exposure during infancy, i.e. the first year of life, may affect lung function development into adolescence. To investigate the association between exposure to air pollution during the first-year of life and lung function development up to the age of 15 in Germany. We investigated 915 children from the GINIplus and LISA birth cohorts from Munich (n = 181) and Wesel (n = 734), who had at least two spirometric measurements at ages 6, 10 and 15. Z-scores of forced expiratory volume in one second (FEV For per interquartile range increase in air pollutants during the first-year life, FEV Infancy exposure to higher air pollution may reduce lung function development up to adolescence, with airway size more affected than lung volume restriction. The potential modifying effects of maternal age, asthmatic status of children and breastfeeding warrant further exploration.
Sections du résumé
BACKGROUND
Limited evidence exists on how air pollution exposure during infancy, i.e. the first year of life, may affect lung function development into adolescence.
OBJECTIVES
To investigate the association between exposure to air pollution during the first-year of life and lung function development up to the age of 15 in Germany.
METHODS
We investigated 915 children from the GINIplus and LISA birth cohorts from Munich (n = 181) and Wesel (n = 734), who had at least two spirometric measurements at ages 6, 10 and 15. Z-scores of forced expiratory volume in one second (FEV
RESULTS
For per interquartile range increase in air pollutants during the first-year life, FEV
DISCUSSION
Infancy exposure to higher air pollution may reduce lung function development up to adolescence, with airway size more affected than lung volume restriction. The potential modifying effects of maternal age, asthmatic status of children and breastfeeding warrant further exploration.
Identifiants
pubmed: 33099064
pii: S0160-4120(20)32150-4
doi: 10.1016/j.envint.2020.106195
pii:
doi:
Substances chimiques
Air Pollutants
0
Particulate Matter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
106195Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.