Primary culture of the rat spinal dorsal horn: a tool to investigate the effects of inflammatory stimulation on the afferent somatosensory system.
Animals
Cells, Cultured
Dinoprostone
/ pharmacology
Female
Glutamic Acid
/ pharmacology
Interleukins
/ genetics
Lipopolysaccharides
/ pharmacology
Male
NF-kappa B
/ genetics
Posterior Horn Cells
/ drug effects
Primary Cell Culture
/ methods
Rats
Rats, Wistar
Spinal Cord Dorsal Horn
/ cytology
Substance P
/ pharmacology
Tumor Necrosis Factor-alpha
/ genetics
Inflammation
Neuronal and glial responses
Primary culture
Somatosensory system
Substantia gelatinosa
Journal
Pflugers Archiv : European journal of physiology
ISSN: 1432-2013
Titre abrégé: Pflugers Arch
Pays: Germany
ID NLM: 0154720
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
22
04
2020
accepted:
14
10
2020
revised:
28
08
2020
pubmed:
25
10
2020
medline:
23
9
2021
entrez:
24
10
2020
Statut:
ppublish
Résumé
One maladaptive consequence of inflammatory stimulation of the afferent somatosensory system is the manifestation of inflammatory pain. We established and characterized a neuroglial primary culture of the rat superficial dorsal horn (SDH) of the spinal cord to test responses of this structure to neurochemical, somatosensory, or inflammatory stimulation. Primary cultures of the rat SDH consist of neurons (43%), oligodendrocytes (35%), astrocytes (13%), and microglial cells (9%). Neurons of the SDH responded to cooling (7%), heating (18%), glutamate (80%), substance P (43%), prostaglandin E
Identifiants
pubmed: 33098464
doi: 10.1007/s00424-020-02478-y
pii: 10.1007/s00424-020-02478-y
pmc: PMC7691309
doi:
Substances chimiques
Interleukins
0
Lipopolysaccharides
0
NF-kappa B
0
Tumor Necrosis Factor-alpha
0
Substance P
33507-63-0
Glutamic Acid
3KX376GY7L
Dinoprostone
K7Q1JQR04M
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1769-1782Commentaires et corrections
Type : CommentIn
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