Multidirectional
Alzheimer Disease
/ metabolism
Amyloid beta-Peptides
/ metabolism
Cholinesterase Inhibitors
/ chemistry
Cholinesterases
/ metabolism
Drug Design
Escherichia coli
Fluorescence Resonance Energy Transfer
Humans
Ligands
Models, Molecular
Protein Aggregates
Receptors, Serotonin
/ metabolism
Structure-Activity Relationship
tau Proteins
/ metabolism
5-HT6 receptor antagonists
Multifunctional ligands
cholinesterase inhibitors
β-secretase
Journal
Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
entrez:
23
10
2020
pubmed:
24
10
2020
medline:
28
5
2021
Statut:
ppublish
Résumé
Effective therapy of Alzheimer's disease (AD) requires treatment with a combination of drugs that modulate various pathomechanisms contributing to the disease. In our research, we have focused on the development of multi-target-directed ligands - 5-HT
Identifiants
pubmed: 33092411
doi: 10.1080/14756366.2020.1835882
pmc: PMC7594877
doi:
Substances chimiques
Amyloid beta-Peptides
0
Cholinesterase Inhibitors
0
Ligands
0
Protein Aggregates
0
Receptors, Serotonin
0
serotonin 6 receptor
0
tau Proteins
0
Cholinesterases
EC 3.1.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1944-1952Références
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