Development of 3D Bioactive Scaffolds through 3D Printing Using Wollastonite-Gelatin Inks.

3D printing bioactive scaffold fish gelatin paste-type ink wollastonite

Journal

Polymers
ISSN: 2073-4360
Titre abrégé: Polymers (Basel)
Pays: Switzerland
ID NLM: 101545357

Informations de publication

Date de publication:
20 Oct 2020
Historique:
received: 17 09 2020
revised: 14 10 2020
accepted: 19 10 2020
entrez: 23 10 2020
pubmed: 24 10 2020
medline: 24 10 2020
Statut: epublish

Résumé

The bioactivity of scaffolds represents a key property to facilitate the bone repair after orthopedic trauma. This study reports the development of biomimetic paste-type inks based on wollastonite (CS) and fish gelatin (FG) in a mass ratio similar to natural bone, as an appealing strategy to promote the mineralization during scaffold incubation in simulated body fluid (SBF). High-resolution 3D scaffolds were fabricated through 3D printing, and the homogeneous distribution of CS in the protein matrix was revealed by scanning electron microscopy/energy-dispersive X-ray diffraction analysis (SEM/EDX) micrographs. The bioactivity of the scaffold was suggested by an outstanding mineralization capacity revealed by the apatite layers deposited on the scaffold surface after immersion in SBF. The biocompatibility was demonstrated by cell proliferation established by MTT assay and fluorescence microscopy images and confirmed by SEM micrographs illustrating cell spreading. This work highlights the potential of the bicomponent inks to fabricate 3D bioactive scaffolds and predicts the osteogenic properties for bone regeneration applications.

Identifiants

DOI: 10.3390/polym12102420 PMID: 33092270 PMC: PMC7589438
pubmed: 33092270
pii: polym12102420
doi: 10.3390/polym12102420
pmc: PMC7589438
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Filis Curti (F)

Advanced Polymer Materials Group, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.

Izabela-Cristina Stancu (IC)

Advanced Polymer Materials Group, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.
ORCID: 0000-0003-0685-3947

Georgeta Voicu (G)

Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.

Horia Iovu (H)

Advanced Polymer Materials Group, Faculty of Applied Chemistry and Material Science, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.

Cristina-Ioana Dobrita (CI)

Department of Biomaterials and Medical Devices, Faculty of Medical Engineering, University Politehnica of Bucharest, 1-7 Gh. Polizu Street, 011061 Bucharest, Romania.

Lucian Toma Ciocan (LT)

Department of Prosthetics Technology and Dental Materials, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474 Bucharest, Romania.

Rodica Marinescu (R)

Department of Orthopedics, "Carol Davila" University of Medicine and Pharmacy, 8 Eroii Sanitari Street, 050474 Bucharest, Romania.

Florin Iordache (F)

Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, 105 Splaiul Independentei, 050097 Bucharest, Romania.

Classifications MeSH