Involvement of MTHFR rs1801133 in the Susceptibility of Acute Lymphoblastic Leukemia: A Preliminary Study.
Journal
Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
received:
22
06
2020
accepted:
14
09
2020
pubmed:
17
10
2020
medline:
3
9
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
Acute lymphoblastic leukemia (ALL), a common blood cancer, is characterized by the interaction between genetic and environmental factors. Several variants of the Methylenetetrahydrofolate reductase (MTHFR), mainly the C677T (rs1801133), may affect susceptibility to ALL. The authors conducted this case-control study to evaluate the relationship between this variant of the MTHFR gene and the risk of ALL. Forty-one patients with ALL and 35 non-ALL controls recruited in this study were genotyped utilizing polymerase chain reaction-restriction fragment length polymorphism methodology. The MTHFR 677CT genotype was significantly more frequently found in patients with ALL having a 2-fold increase in risk (P <0.01). Our results suggest that rs1801133 of MTHFR is a predictive risk marker to ALL in Tunisian ALL.
Sections du résumé
BACKGROUND
Acute lymphoblastic leukemia (ALL), a common blood cancer, is characterized by the interaction between genetic and environmental factors. Several variants of the Methylenetetrahydrofolate reductase (MTHFR), mainly the C677T (rs1801133), may affect susceptibility to ALL.
AIM OF THE STUDY
The authors conducted this case-control study to evaluate the relationship between this variant of the MTHFR gene and the risk of ALL.
MATERIALS AND METHODS
Forty-one patients with ALL and 35 non-ALL controls recruited in this study were genotyped utilizing polymerase chain reaction-restriction fragment length polymorphism methodology.
RESULTS
The MTHFR 677CT genotype was significantly more frequently found in patients with ALL having a 2-fold increase in risk (P <0.01).
CONCLUSION
Our results suggest that rs1801133 of MTHFR is a predictive risk marker to ALL in Tunisian ALL.
Identifiants
pubmed: 33060392
pii: 00043426-202108000-00027
doi: 10.1097/MPH.0000000000001970
doi:
Substances chimiques
MTHFR protein, human
EC 1.5.1.20
Methylenetetrahydrofolate Reductase (NADPH2)
EC 1.5.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e816-e818Informations de copyright
Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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