The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation.

IL-13 IL-33 PD-1 ST2 acute lung injury group 2 innate lymphoid cells natural and inflammatory ILC2 sepsis

Journal

Diagnostics (Basel, Switzerland)
ISSN: 2075-4418
Titre abrégé: Diagnostics (Basel)
Pays: Switzerland
ID NLM: 101658402

Informations de publication

Date de publication:
12 Oct 2020
Historique:
received: 19 09 2020
revised: 06 10 2020
accepted: 09 10 2020
entrez: 15 10 2020
pubmed: 16 10 2020
medline: 16 10 2020
Statut: epublish

Résumé

Septic shock/severe sepsis is a deregulated host immune system response to infection that leads to life-threatening organ dysfunction. Lung inflammation as a form of acute lung injury (ALI) is often induced in septic shock. Whereas macrophages and neutrophils have been implicated as the principal immune cells regulating lung inflammation, group two innate lymphoid cells (ILC2s) have recently been identified as a new player regulating immune homeostasis. ILC2 is one of the three major ILC subsets (ILC1s, ILC2s, and ILC3s) comprised of newly identified innate immune cells. These cells are characterized by their ability to rapidly produce type 2 cytokines. ILC2s are predominant resident ILCs and, thereby, have the ability to respond to signals from damaged tissues. ILC2s regulate the immune response, and ILC2-derived type 2 cytokines may exert protective roles against sepsis-induced lung injury. This focused review not only provides readers with new insights into the signaling mechanisms by which ILC2s modulate sepsis-induced lung inflammation, but also proposes ILC2 as a novel therapeutic target for sepsis-induced ALI.

Identifiants

DOI: 10.3390/diagnostics10100808 PMID: 33053762 PMC: PMC7600279
pubmed: 33053762
pii: diagnostics10100808
doi: 10.3390/diagnostics10100808
pmc: PMC7600279
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : Japan Society for the Promotion of Science
ID : 19K18317
Organisme : Japan Society for the Promotion of Science
ID : 18K07189
Organisme : Japan Society for the Promotion of Science
ID : 18H02622
Organisme : Japan Society for the Promotion of Science
ID : 19KK0196
Organisme : Okasan-Kato Foundation
ID : 19-1-21

Références

N Engl J Med. 2017 Aug 10;377(6):562-572
pubmed: 28792873
J Exp Med. 2018 Jan 2;215(1):263-281
pubmed: 29222107
Nat Immunol. 2016 Jan;17(1):57-64
pubmed: 26523868
Int Immunol. 2016 Jan;28(1):23-8
pubmed: 26232596
J Allergy Clin Immunol. 2014 Apr;133(4):1142-8
pubmed: 24679471
J Allergy Clin Immunol. 2014 Sep;134(3):671-678.e4
pubmed: 25171868
Front Immunol. 2019 Jun 07;10:930
pubmed: 31231357
Thorax. 2020 Mar;75(3):209-219
pubmed: 31937554
Wellcome Open Res. 2017 Dec 14;2:117
pubmed: 29588921
Nat Immunol. 2015 Feb;16(2):161-9
pubmed: 25531830
J Infect Dis. 2014 Aug 1;210(3):493-503
pubmed: 24577508
Pathog Dis. 2013 Nov;69(2):127-41
pubmed: 23929557
J Exp Med. 2017 Jun 5;214(6):1663-1678
pubmed: 28490441
Nature. 2010 Apr 29;464(7293):1367-70
pubmed: 20200518
Lancet Infect Dis. 2013 Mar;13(3):260-8
pubmed: 23427891
Nat Immunol. 2013 Mar;14(3):221-9
pubmed: 23334791
N Engl J Med. 2000 May 4;342(18):1301-8
pubmed: 10793162
Immunity. 2012 Sep 21;37(3):463-74
pubmed: 22981535
N Engl J Med. 2006 Jun 15;354(24):2564-75
pubmed: 16714767
Nat Immunol. 2011 Jan;12(1):21-7
pubmed: 21113163
J Allergy Clin Immunol. 2015 Jul;136(1):59-68.e14
pubmed: 25617223
N Engl J Med. 2014 May 29;370(22):2102-10
pubmed: 24846652
Int J Mol Sci. 2017 Nov 14;18(11):
pubmed: 29135922
Science. 2015 Nov 20;350(6263):981-5
pubmed: 26472762
Immunity. 2014 Aug 21;41(2):283-95
pubmed: 25088770
Immunity. 2009 Jul 17;31(1):84-98
pubmed: 19559631
JAMA. 2016 Feb 23;315(8):801-10
pubmed: 26903338
Mucosal Immunol. 2018 Jan;11(1):61-70
pubmed: 28488693
Nat Rev Immunol. 2013 Feb;13(2):145-9
pubmed: 23348417
Cell. 2018 Aug 23;174(5):1054-1066
pubmed: 30142344
Shock. 2020 Aug 20;:
pubmed: 32826811
Crit Care Med. 2016 Apr;44(4):782-9
pubmed: 26741580
Int Immunol. 1996 May;8(5):765-72
pubmed: 8671665
Annu Rev Immunol. 2008;26:677-704
pubmed: 18173375
Crit Care. 2011;15(1):R70
pubmed: 21349174
J Immunol. 2009 Nov 15;183(10):6469-77
pubmed: 19841166
Cell Rep. 2018 Nov 20;25(8):2053-2060.e4
pubmed: 30463004
Nat Commun. 2013;4:2675
pubmed: 24157859
Shock. 2017 Jul;48(1):119-129
pubmed: 27941591
Am J Respir Crit Care Med. 2012 Aug 1;186(3):246-54
pubmed: 22652030
Immunity. 2020 Jan 14;52(1):96-108.e9
pubmed: 31810881
Front Immunol. 2017 Apr 24;8:475
pubmed: 28484466
Nat Commun. 2020 Jan 7;11(1):35
pubmed: 31911623
J Immunol. 2012 Apr 1;188(7):3488-95
pubmed: 22371395
J Allergy Clin Immunol. 2016 Jan;137(1):75-86.e8
pubmed: 26194544
Int Immunol. 1996 May;8(5):773-80
pubmed: 8671666
Cell. 2017 Nov 2;171(4):795-808.e12
pubmed: 29056343
J Immunol. 2016 Mar 1;196(5):2410-23
pubmed: 26829987
Nat Immunol. 2011 Nov;12(11):1045-54
pubmed: 21946417
Immunity. 2020 Apr 14;52(4):635-649.e4
pubmed: 32240600
IUBMB Life. 2004 Apr;56(4):185-91
pubmed: 15230345
Nat Commun. 2017 Apr 04;8:14919
pubmed: 28374774
Nature. 2017 Sep 14;549(7671):277-281
pubmed: 28869974
J Allergy Clin Immunol. 2019 May;143(5):1769-1782.e11
pubmed: 30414858
Science. 2018 Mar 2;359(6379):1056-1061
pubmed: 29496881
Nature. 2010 Jan 28;463(7280):540-4
pubmed: 20023630
J Exp Med. 2017 Sep 4;214(9):2507-2521
pubmed: 28747424
Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S263-70
pubmed: 25525730
Nat Immunol. 2015 Jan;16(1):45-56
pubmed: 25521684
Immunity. 2015 Feb 17;42(2):216-226
pubmed: 25692699
J Immunol. 1998 Nov 1;161(9):4866-74
pubmed: 9794420
Nature. 2009 Feb 5;457(7230):722-5
pubmed: 18978771
Cell Host Microbe. 2015 Jul 8;18(1):27-37
pubmed: 26159718
Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10762-7
pubmed: 26243875
J Allergy Clin Immunol. 2008 Jun;121(6):1484-90
pubmed: 18539196
Immunity. 2018 Jun 19;48(6):1195-1207.e6
pubmed: 29907525
J Leukoc Biol. 2019 Jan;105(1):143-150
pubmed: 30260499
Shock. 2013 Nov;40(5):375-81
pubmed: 23903852
Nat Commun. 2016 Apr 21;7:11394
pubmed: 27099134
Mucosal Immunol. 2019 Mar;12(2):299-311
pubmed: 30664706
Crit Care. 2018 Nov 22;22(1):322
pubmed: 30466493
Am J Pathol. 2018 Sep;188(9):2097-2108
pubmed: 29935165
Immunity. 2012 Jan 27;36(1):55-67
pubmed: 22261438
Pulm Pharmacol Ther. 2016 Aug;39:54-63
pubmed: 27354118
Front Immunol. 2018 Sep 19;9:2132
pubmed: 30283458
Immunity. 2008 Dec 19;29(6):958-70
pubmed: 19084435
J Leukoc Biol. 2010 Aug;88(2):233-40
pubmed: 20483923
Immunity. 2005 Nov;23(5):479-90
pubmed: 16286016
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6930-5
pubmed: 9618516
Crit Care. 2019 May 31;23(1):196
pubmed: 31151462
J Exp Med. 2017 Jan;214(1):27-37
pubmed: 28011865
Cell Death Dis. 2018 Mar 6;9(3):369
pubmed: 29511181
Nat Rev Immunol. 2018 Mar;18(3):153-167
pubmed: 28990585
Immunity. 2014 Mar 20;40(3):425-35
pubmed: 24613091
J Immunol. 2000 Mar 1;164(5):2738-44
pubmed: 10679115
PLoS Med. 2017 Jul 25;14(7):e1002365
pubmed: 28742815
Nat Immunol. 2009 Jan;10(1):66-74
pubmed: 19029905
Chest. 1999 Jul;116(1 Suppl):74S-82S
pubmed: 10424602
Nature. 2014 Sep 25;513(7519):564-568
pubmed: 25043027
JCI Insight. 2019 Mar 21;4(6):
pubmed: 30721149
Science. 2018 Jan 5;359(6371):114-119
pubmed: 29302015
J Exp Med. 2013 Dec 16;210(13):2951-65
pubmed: 24249111

Auteurs

Yuichi Akama (Y)

Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.
Department of Emergency and Disaster Medicine, Faculty, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.
ORCID: 0000-0002-7040-1307

Naoko Satoh-Takayama (N)

Laboratory for Intestinal Ecosystem, Center for Integrative Medical Sciences, RIKEN, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.
Immunobiology Laboratory, Graduate School of Medical Life Science, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan.

Eiji Kawamoto (E)

Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.
Department of Emergency and Disaster Medicine, Faculty, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.

Atsushi Ito (A)

Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.
Department of Thoracic and Cardiovascular Surgery, Faculty, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.

Arong Gaowa (A)

Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.

Eun Jeong Park (EJ)

Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.
ORCID: 0000-0002-4288-5893

Hiroshi Imai (H)

Department of Emergency and Disaster Medicine, Faculty, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.

Motomu Shimaoka (M)

Department of Molecular Pathobiology and Cell Adhesion Biology, Graduate School of Medicine, Mie University, 2-174 Edobashi, Tsu City, Mie 514-8507, Japan.

Classifications MeSH