Astrocytes Protect Human Dopaminergic Neurons from α-Synuclein Accumulation and Propagation.
Adult
Astrocytes
/ physiology
Coculture Techniques
Dopaminergic Neurons
/ metabolism
Exosomes
/ metabolism
Female
Humans
Induced Pluripotent Stem Cells
Lysosomes
/ enzymology
Male
Neuroglia
/ metabolism
Parkinsonian Disorders
/ genetics
Proton-Translocating ATPases
/ deficiency
Synucleinopathies
/ genetics
alpha-Synuclein
/ biosynthesis
Kufor–Rakeb syndrome
Parkinson's disease
astrocyte
α-synuclein
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140
Informations de publication
Date de publication:
04 11 2020
04 11 2020
Historique:
received:
23
04
2020
revised:
18
08
2020
accepted:
01
09
2020
pubmed:
14
10
2020
medline:
2
2
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
The pathologic hallmark of Parkinson's disease is the accumulation of α-synuclein-containing Lewy bodies/neurites almost exclusively in neurons, and rarely in glial cells. However, emerging evidence suggests that glia such as astrocytes play an important role in the development of α-synuclein pathology. Using induced pluripotent stem-derived dopaminergic neurons and astrocytes from healthy subjects and patients carrying mutations in lysosomal
Identifiants
pubmed: 33046546
pii: JNEUROSCI.0954-20.2020
doi: 10.1523/JNEUROSCI.0954-20.2020
pmc: PMC7643299
doi:
Substances chimiques
ATP13A2 protein, human
0
alpha-Synuclein
0
Proton-Translocating ATPases
EC 3.6.3.14
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8618-8628Subventions
Organisme : NINDS NIH HHS
ID : K00 NS105182
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS096241
Pays : United States
Informations de copyright
Copyright © 2020 the authors.
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