Cerebrovascular Reactivity Assays Collateral Function in Carotid Stenosis.
MRI
cerebral blood flow
cerebrovascular disease
cerebrovascular reactivity
collaterals
stroke
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2020
2020
Historique:
received:
03
06
2020
accepted:
28
07
2020
entrez:
12
10
2020
pubmed:
13
10
2020
medline:
13
10
2020
Statut:
epublish
Résumé
In patients with carotid artery stenosis (CAS), the risk of stroke, its severity, and response to revascularization are strongly related to the availability of collateral blood flow. Unfortunately, there is poor agreement between observers in assessing collateral flow using flow-based imaging. We used changes in blood-oxygen-level-dependent (BOLD) MRI as a surrogate of changes in regional cerebral blood flow in response to a hypercapnic stimulus [i.e., cerebrovascular reactivity (CVR)] as indicating flow reserve ipsilateral to CAS. We hypothesized that some patients with hemodynamically significant CAS develop functional collateral flow as indicated by normalization of ipsilateral CVR. We identified 55 patients in our CVR database with various degrees of CAS assessed by angiography and classed them as <50% stenosis, 50-69% stenosis, 70-90% stenosis, >90% stenosis, and full occlusion. CVR was measured as the change in BOLD signal in response to changes in end-tidal partial pressure of CO
Identifiants
pubmed: 33041841
doi: 10.3389/fphys.2020.01031
pmc: PMC7528398
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1031Informations de copyright
Copyright © 2020 Sobczyk, Sam, Mandell, Crawley, Venkatraghavan, McKetton, Poublanc, Duffin, Fisher and Mikulis.
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