Sex Differences in Diabetes- and TGF-β1-Induced Renal Damage.
DHT
TGF-β1
diabetes mellitus
diabetic nephropathy
estradiol
kidney
sex differences
testosterone
transforming growth factor beta 1
tubulointerstitial fibrosis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
03 10 2020
03 10 2020
Historique:
received:
31
08
2020
revised:
24
09
2020
accepted:
01
10
2020
entrez:
7
10
2020
pubmed:
8
10
2020
medline:
5
8
2021
Statut:
epublish
Résumé
While females are less affected by non-diabetic kidney diseases compared to males, available data on sex differences in diabetic nephropathy (DN) are controversial. Although there is evidence for an imbalance of sex hormones in diabetes and hormone-dependent mechanisms in transforming growth factor β1 (TGF-β1) signaling, causes and consequences are still incompletely understood. Here we investigated the influence of sex hormones and sex-specific gene signatures in diabetes- and TGF-β1-induced renal damage using various complementary approaches (a
Identifiants
pubmed: 33023010
pii: cells9102236
doi: 10.3390/cells9102236
pmc: PMC7600610
pii:
doi:
Substances chimiques
TGFB1 protein, human
0
Transforming Growth Factor beta1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.
Références
Endocr Rev. 2016 Jun;37(3):278-316
pubmed: 27159875
Mol Biol Cell. 1993 Feb;4(2):135-44
pubmed: 8382975
Gend Med. 2008;5 Suppl A:S3-S10
pubmed: 18395681
Biochem Biophys Res Commun. 2009 May 22;383(1):1-3
pubmed: 19303394
Med Electron Microsc. 2002 Jun;35(2):87-95
pubmed: 12181650
Diabetes Care. 1994 May;17(5):405-11
pubmed: 8062607
Semin Nephrol. 2012 Sep;32(5):452-62
pubmed: 23062986
Int J Obes Relat Metab Disord. 1998 Apr;22(4):318-24
pubmed: 9578236
J Histochem Cytochem. 2012 Dec;60(12):976-86
pubmed: 23103723
Biochim Biophys Acta. 2009 Jul;1793(7):1165-73
pubmed: 19339207
Am J Physiol Renal Physiol. 2009 Aug;297(2):F307-15
pubmed: 19493965
Semin Nephrol. 2012 May;32(3):261-8
pubmed: 22835457
J Am Soc Nephrol. 2003 May;14(5):1358-73
pubmed: 12707406
BMC Physiol. 2006 May 30;6:4
pubmed: 16734901
Proc Natl Acad Sci U S A. 1993 Mar 1;90(5):1814-8
pubmed: 7680480
Clin Endocrinol (Oxf). 2009 Apr;70(4):547-53
pubmed: 18702678
Diabetes Care. 1999 Sep;22(9):1555-60
pubmed: 10480525
Am J Physiol Renal Physiol. 2005 Feb;288(2):F399-405
pubmed: 15454392
PLoS One. 2014 Feb 12;9(2):e89233
pubmed: 24533170
Steroids. 2010 Nov;75(11):779-87
pubmed: 20064538
Cell. 2003 Jun 13;113(6):685-700
pubmed: 12809600
Lab Invest. 2015 Jun;95(6):697
pubmed: 26012704
Kidney Dis (Basel). 2016 Oct;2(3):136-144
pubmed: 27921041
Am J Physiol Renal Physiol. 2011 Sep;301(3):F634-40
pubmed: 21653631
J Am Soc Nephrol. 2000 Feb;11(2):319-29
pubmed: 10665939
Diabet Med. 2003 Jul;20(7):580-5
pubmed: 12823241
Clin J Am Soc Nephrol. 2017 Dec 7;12(12):2032-2045
pubmed: 28522654
JAMA. 2006 Mar 15;295(11):1288-99
pubmed: 16537739
Am J Pathol. 2005 Jun;166(6):1629-36
pubmed: 15920148
Clin Exp Nephrol. 2005 Jun;9(2):114-21
pubmed: 15980944
Trends Endocrinol Metab. 2016 Oct;27(10):681-695
pubmed: 27372267
Shock. 2012 Feb;37(2):191-6
pubmed: 22249220
Kidney Int. 2003 Jun;63(6):2037-49
pubmed: 12753291
Endocrinology. 2012 Jan;153(1):254-63
pubmed: 22067314
Diabetes Care. 2004 Apr;27(4):861-8
pubmed: 15047639
Hypertension. 2002 Dec;40(6):853-8
pubmed: 12468569
Gend Med. 2005 Dec;2(4):227-37
pubmed: 16464734
Nephrol Dial Transplant. 2013 Nov;28(11):2678-81
pubmed: 23975753
Pediatr Nephrol. 2001 Jan;16(1):61-8
pubmed: 11198606
Biochim Biophys Acta. 1997 Oct 24;1333(2):F105-50
pubmed: 9395284
J Clin Med. 2015 May 28;4(6):1207-16
pubmed: 26239554
Dev Biol. 2011 Jan 15;349(2):417-26
pubmed: 20969841
J Nephrol. 2009 May-Jun;22(3):403-10
pubmed: 19557718
Nephrol Dial Transplant. 1989;4(10):859-63
pubmed: 2515489
Int J Biochem Cell Biol. 2006 Jan;38(1):1-5
pubmed: 16230044
Curr Opin Nephrol Hypertens. 2004 May;13(3):279-84
pubmed: 15073485
J Cell Biochem. 2008 Feb 1;103(2):383-92
pubmed: 17541956
Am J Physiol Renal Physiol. 2007 Jun;292(6):F1681-90
pubmed: 17311907
Eur J Clin Invest. 2009 Aug;39(8):631-48
pubmed: 19496803
Matrix Biol. 2018 Aug;68-69:248-262
pubmed: 29425694
Nat Med. 2003 Jul;9(7):964-8
pubmed: 12808448
Gend Med. 2008;5 Suppl A:S103-13
pubmed: 18395675
Diabetes Care. 2006 Feb;29(2):312-6
pubmed: 16443879
Diabetologia. 2011 Aug;54(8):1943-5
pubmed: 21597998
Kidney Int. 2004 Nov;66(5):1849-58
pubmed: 15496155
Am J Physiol Regul Integr Comp Physiol. 2011 May;300(5):R1009-22
pubmed: 21228342
J Clin Endocrinol Metab. 2005 Aug;90(8):4516-20
pubmed: 15886254
Histol Histopathol. 2002 Jan;17(1):247-52
pubmed: 11813875
Endocrinology. 2009 Apr;150(4):2000-7
pubmed: 19008314
Kidney Int. 2013 Dec;84(6):1129-44
pubmed: 23868013
Clin Endocrinol (Oxf). 1996 Nov;45(5):615-21
pubmed: 8977760
Nat Med. 2010 May;16(5):535-43, 1p following 143
pubmed: 20436483
J Am Soc Nephrol. 2008 Nov;19(11):2098-107
pubmed: 18632843
Pediatr Nephrol. 2000 Dec;15(3-4):290-301
pubmed: 11149129
Cytotechnology. 2016 Aug;68(4):987-98
pubmed: 25749915
Diabetes Care. 2000 Apr;23(4):490-4
pubmed: 10857940
Am J Physiol Renal Physiol. 2016 Mar 9;310(10):F945-F957
pubmed: 26962103
Curr Opin Nephrol Hypertens. 2011 May;20(3):278-84
pubmed: 21422926
J Dev Biol. 2018 Jun 16;6(2):
pubmed: 29914150
Am J Physiol Renal Physiol. 2005 Apr;288(4):F800-9
pubmed: 15536170
Endocrine. 2005 Aug;27(3):301-5
pubmed: 16230788
Hypertension. 2008 Apr;51(4):1218-24
pubmed: 18259041
J Am Soc Nephrol. 2001 Nov;12(11):2392-9
pubmed: 11675415
J Clin Endocrinol Metab. 2008 May;93(5):1834-40
pubmed: 18319314
Am J Physiol Renal Physiol. 2009 Apr;296(4):F680-8
pubmed: 19144692
Biochem J. 2008 Dec 15;416(3):453-62
pubmed: 18651839
Nephrol Dial Transplant. 2017 Feb 1;32(2):224-233
pubmed: 28186539
Am J Nephrol. 2010;31(1):68-74
pubmed: 19887790
Eur J Clin Invest. 2004 Dec;34(12):785-96
pubmed: 15606719