Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.
ATP-binding cassette (ABC) transporter(s)
Breast cancer resistance protein (BCRP)
Drug transport
Efflux pumps
MDCK cells
Membrane transporter
P-glycoprotein (P-gp)
Permeability
Proteomics
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
12
08
2020
revised:
23
09
2020
accepted:
27
09
2020
pubmed:
3
10
2020
medline:
22
6
2021
entrez:
2
10
2020
Statut:
ppublish
Résumé
The Breast Cancer Resistance Protein (BCRP) is a key transporter in drug efflux and drug-drug interactions. However, endogenous expression of Multidrug Resistance Protein 1 (MDR1) confounds the interpretation of BCRP-mediated transport in in vitro models. Here we used a CRISPR-Cas9 edited Madin-Darby canine kidney (MDCK) II cell line (MDCK
Identifiants
pubmed: 33007277
pii: S0022-3549(20)30569-4
doi: 10.1016/j.xphs.2020.09.039
pii:
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B, Member 1
0
ATP Binding Cassette Transporter, Subfamily G, Member 2
0
Neoplasm Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
388-396Informations de copyright
Copyright © 2020 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.