Mechanisms underlying the selectivity of meta-diamides between insect resistance to dieldrin (RDL) and human γ-aminobutyric acid (GABA) and glycine receptors.
RDL GABA receptor
glycine receptor
human GABA type A receptor
meta-diamide
Journal
Pest management science
ISSN: 1526-4998
Titre abrégé: Pest Manag Sci
Pays: England
ID NLM: 100898744
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
revised:
22
09
2020
received:
24
07
2020
accepted:
01
10
2020
pubmed:
2
10
2020
medline:
6
7
2021
entrez:
1
10
2020
Statut:
ppublish
Résumé
Meta-diamides [3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzamides] show high insecticide activity by acting as antagonists to the insect resistance to dieldrin (RDL) γ-aminobutyric acid (GABA) receptors. In contrast, low-level antagonist activities of meta-diamides have been demonstrated against the human GABA type A receptor (GABA We examined the effects of an equivalent mutation (M288G) in spontaneously opened human GABA Studies substituting an equivalent mutation (M288G) in spontaneously opening human GABA
Sections du résumé
BACKGROUND
BACKGROUND
Meta-diamides [3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzamides] show high insecticide activity by acting as antagonists to the insect resistance to dieldrin (RDL) γ-aminobutyric acid (GABA) receptors. In contrast, low-level antagonist activities of meta-diamides have been demonstrated against the human GABA type A receptor (GABA
RESULTS
RESULTS
We examined the effects of an equivalent mutation (M288G) in spontaneously opened human GABA
CONCLUSION
CONCLUSIONS
Studies substituting an equivalent mutation (M288G) in spontaneously opening human GABA
Substances chimiques
Drosophila Proteins
0
Rdl protein, Drosophila
0
Receptors, GABA-A
0
Receptors, Glycine
0
Diamide
10465-78-8
gamma-Aminobutyric Acid
56-12-2
Dieldrin
I0246D2ZS0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3744-3752Informations de copyright
© 2020 Society of Chemical Industry.
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