Human Cytomegalovirus Envelope Protein gpUL132 Regulates Infectious Virus Production through Formation of the Viral Assembly Compartment.
human cytomegalovirus
viral assembly compartment
virion envelope protein
virus glycoproteins
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
29 09 2020
29 09 2020
Historique:
entrez:
30
9
2020
pubmed:
1
10
2020
medline:
21
7
2021
Statut:
epublish
Résumé
The human cytomegalovirus (HCMV) UL132 open reading frame encodes a 270-amino-acid type I envelope glycoprotein, gpUL132. The deletion of UL132 (ΔUL132) from the HCMV genome results in a pronounced deficit in virus yield, with an approximately 2-log decrease in the production of infectious virus compared to the wild-type (WT) virus. Characterization of the ΔUL132 mutant virus indicated that it was less infectious with a high particle-to-infectious unit ratio and an altered composition of virion proteins compared to the WT virus. In addition, the viral assembly compartment (AC) failed to form in cells infected with the ΔUL132 mutant virus. The expression of gpUL132 in
Identifiants
pubmed: 32994323
pii: mBio.02044-20
doi: 10.1128/mBio.02044-20
pmc: PMC7527726
pii:
doi:
Substances chimiques
Membrane Glycoproteins
0
Viral Envelope Proteins
0
Viral Proteins
0
gpUL132 protein, human cytomegalovirus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI035602
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI120619
Pays : United States
Informations de copyright
Copyright © 2020 Wu et al.
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